Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors

Timothy J. Burbridge, Hong Ping Xu, James B. Ackman, Xinxin Ge, Yueyi Zhang, Mei Jun Ye, Z. Jimmy Zhou, Jian Xu, Anis Contractor, Michael C. Crair*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In sensory systems, patterned spontaneous activity before the onset of sensation is thought to influence this process, but this conclusion remains controversial, largely due to the inherent difficulty recording neural activity in early development. Here, we describe genetic and pharmacological manipulations of spontaneous retinal activity, assayed invivo, that demonstrate a causal link between retinal waves and visual circuit refinement. We also report a decoupling of downstream activity in retinorecipient regions of the developing brain after retinal wave disruption. Significantly, we show that the spatiotemporal characteristics of retinal waves affect the development of specific visual circuits. These results conclusively establish retinal waves as necessary and instructive for circuit refinement in the developing nervous system and reveal how neural circuits adjust to altered patterns of activity prior to experience.

Original languageEnglish (US)
Pages (from-to)1049-1064
Number of pages16
JournalNeuron
Volume84
Issue number5
DOIs
StatePublished - Dec 3 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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