Visual Evoked Potentials as a Readout of Cortical Function in Infants with Tuberous Sclerosis Complex

Kandice J. Varcin, Charles A. Nelson*, Jordan Ko, Mustafa Sahin, Joyce Y. Wu, Shafali Spurling Jeste

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Tuberous sclerosis complex is an autosomal dominant genetic disorder that confers a high risk for neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. Studies have demonstrated specific delays in visual reception skills that may predict the development of autism spectrum disorder and intellectual disability. Based on evidence for alterations in the retinogeniculate pathway in animal models of tuberous sclerosis complex, we asked whether children with tuberous sclerosis complex demonstrate alterations in early visual processing that may undermine the development of higher-level visual behaviors. Pattern-reversal visual evoked potentials were recorded in infants with tuberous sclerosis complex (n = 16) and typically developing infants (n = 18) at 12 months of age. Infants with tuberous sclerosis complex demonstrated remarkably intact visual evoked potentials even within the context of intellectual disability and epilepsy. Infants with tuberous sclerosis complex show intact visual cortical processing, suggesting that delays in visually mediated behaviors in tuberous sclerosis complex may not be rooted in early visual processing deficits.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalJournal of child neurology
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • event-related potentials
  • neurodevelopmental disorders
  • tuberous sclerosis complex
  • visual evoked potentials
  • visual processing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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