Visual field outcomes in children treated for neurofibromatosis type 1–associated optic pathway gliomas: a multicenter retrospective study

Gena Heidary*, Michael J. Fisher, Grant T. Liu, Rosalie E. Ferner, David H. Gutmann, Robert H. Listernick, Kush Kapur, Michael Loguidice, Simone L. Ardern-Holmes, Robert A. Avery, Christopher Hammond, Robert O. Hoffman, Trent R. Hummel, Annie Kuo, Arun Reginald, Nicole J. Ullrich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Optic pathway gliomas associated with neurofibromatosis type 1 (NF1-OPGs) may adversely affect visual acuity, but data regarding visual field (VF) outcomes after treatment in children are limited. The purpose of this study was to investigate the effects of NF1-OPGs on VF function in a large cohort of children after treatment with chemotherapy. Methods: We performed a retrospective, international, multicenter study of VF outcomes in patients treated with chemotherapy for NF1-OPGs. Results: A total of 25 participants underwent VF testing using formal perimetric techniques. At the end of treatment, 19 participants (76%) had persistent VF deficits. Formal VF testing was available for 16 participants (64%) at initiation and completion of treatment. Of the 16 children who underwent VF testing at initiation and completion of treatment, 7 (44%) showed stability of VF changes, 3 (19%) showed improvement of VF function, and 6 (38%) had worsening of VFs. Improvement or worsening of VF outcome did not always correlate with visual acuity outcome. Posterior tumor location involving the optic tracts and radiations was associated with more frequent and more profound VF defects. Conclusions: In our study cohort, children undergoing initial chemotherapy for NF1-OPGs had a high prevalence of VF loss, which could be independent of visual acuity loss. A larger, prospective study is necessary to fully determine the prevalence of VF loss and the effects of chemotherapy on VF outcomes in children with NF1-OPGs.

Original languageEnglish (US)
JournalJournal of AAPOS
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Fingerprint Dive into the research topics of 'Visual field outcomes in children treated for neurofibromatosis type 1–associated optic pathway gliomas: a multicenter retrospective study'. Together they form a unique fingerprint.

Cite this