Visual Morbidity in Ocular Tuberculosis–Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ilaria Testi, Ester Carreño, Mark Westcott, Sarakshi Mahajan, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Soon Phaik Chee, Peter Mccluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef KhairallahNicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanaya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up (p < .001). Mean BCVA was worse at 12–18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalOcular Immunology and Inflammation
Issue numbersup1
StatePublished - 2020


  • Tuberculosis
  • blindness
  • uveitis
  • visual impairment
  • visual morbidity

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


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