Visualization of iliac and proximal femoral artery hemodynamics using time-resolved 3D phase contrast MRI at 3T

Alex Frydrychowicz*, Jan T. Winterer, Maxim Zaitsev, Bernd Jung, Jürgen Hennig, Mathias Langer, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Purpose: To demonstrate the feasibility of time-resolved 3D MR velocity mapping at 3 Tesla for the visualization of vascular hemodynamics in normal iliac and femoral arteries. Materials and Methods: Electrocardiographically (ECG) synchronized three-dimensional (3D) CINE phase-contrast MRI with three-directional flow encoding was adapted to analyze flow in peripheral arteries at 3T. Visualization of peripheral arterial hemodynamics within the acquired data volume included 3D streamlines and time-resolved 3D particle traces within the major vessels and localized analysis of flow profiles using 2D-vector graphs. Data was visually compared to results from color-coded duplex ultrasound (US). Results: Global and detailed local blood flow characteristics were successfully analyzed in all subjects. In agreement with US findings, normal laminar flow patterns without flow acceleration or disturbances were visualized in all healthy individuals. In an exemplary patient measurement multiple segmental flow accelerations could be demonstrated. MRI additionally revealed complex helical flow alterations distal to a moderate stenosis. Conclusion: Due to the full spatial and temporal coverage of the arteries of interest, 3D CINE phase contrast MRI at 3T is a promising tool for the evaluation of vascular hemodynamics in peripheral arteries. Future methodological improvements will be directed to improve spatial and temporal resolution as well as quantitative data analysis. Moreover, the technique will have to be evaluated in patients in comparison to standard diagnostic tools.

Original languageEnglish (US)
Pages (from-to)1085-1092
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - May 2007


  • Angiography
  • Femoral artery
  • Hemodynamics
  • Iliac artery
  • MRI
  • Peripheral arterial occlusive diseases
  • Phase-contrast
  • Visualization techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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