Visualizing cortical activation during mental calculation with functional MRI

Linda Rueckert, Nicholas Lange, Arnaud Partiot, Ildebrando Appollonio, Irene Litvan, Denis Le Bihan, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

Cortical activation during arithmetic calculation (silent subtraction by sevens) was compared to that observed during a control condition for which subjects were required to count forward by ones. Nine normal subjects underwent 1.5-T functional magnetic resonance imaging while performing these tasks. All subjects showed bilateral premotor, posterior parietal, and prefrontal cortex activation during serial calculation. There was a large degree of individual variation in activation outside of these areas. These results confirm the role of posterior parietal cortex in arithmetic calculation and implicate parietal cortex in arithmetic calculation and implicate other regions, including prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalNeuroimage
Volume3
Issue number2
DOIs
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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