Visualizing mitochondrial (dys)function using positron emission tomography imaging

Anand Srivastava, Pottumarthi V. Prasad*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

Abstract

Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.

Original languageEnglish (US)
Pages (from-to)51-53
Number of pages3
JournalKidney international
Volume98
Issue number1
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Nephrology

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