Visualizing mitochondrial (dys)function using positron emission tomography imaging

Anand Srivastava; Pottumarthi V. Prasad

doi:10.1016/j.kint.2020.03.021

Visualizing mitochondrial (dys)function using positron emission tomography imaging

Anand Srivastava, Pottumarthi V. Prasad^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-¹⁸F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (¹⁸F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of ¹⁸F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.

Original language	English (US)
Pages (from-to)	51-53
Number of pages	3
Journal	Kidney international
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.kint.2020.03.021
State	Published - Jul 2020

ASJC Scopus subject areas

Nephrology

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@article{35d81e898b0a40b29128485486603251,

title = "Visualizing mitochondrial (dys)function using positron emission tomography imaging",

abstract = "Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.",

author = "Anand Srivastava and Prasad, {Pottumarthi V.}",

note = "Funding Information: AS is supported by National Institutes of Health grant K23DK120811 , the Dixon Translational Research Grants Initiative at Northwestern Medicine and the Northwestern University Clinical and Translational Sciences Institute ( UL1TR001422 ), and core resources from the George M. O{\textquoteright}Brien Kidney Research Center at Northwestern University (NU-GoKIDNEY) P30DK114857. PVP is supported in part by R01DK106557.",

year = "2020",

month = jul,

doi = "10.1016/j.kint.2020.03.021",

language = "English (US)",

volume = "98",

pages = "51--53",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Visualizing mitochondrial (dys)function using positron emission tomography imaging

AU - Srivastava, Anand

AU - Prasad, Pottumarthi V.

N1 - Funding Information: AS is supported by National Institutes of Health grant K23DK120811 , the Dixon Translational Research Grants Initiative at Northwestern Medicine and the Northwestern University Clinical and Translational Sciences Institute ( UL1TR001422 ), and core resources from the George M. O’Brien Kidney Research Center at Northwestern University (NU-GoKIDNEY) P30DK114857. PVP is supported in part by R01DK106557.

PY - 2020/7

Y1 - 2020/7

N2 - Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.

AB - Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.

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