TY - JOUR
T1 - Visualizing mitochondrial (dys)function using positron emission tomography imaging
AU - Srivastava, Anand
AU - Prasad, Pottumarthi V.
N1 - Funding Information:
AS is supported by National Institutes of Health grant K23DK120811 , the Dixon Translational Research Grants Initiative at Northwestern Medicine and the Northwestern University Clinical and Translational Sciences Institute ( UL1TR001422 ), and core resources from the George M. O’Brien Kidney Research Center at Northwestern University (NU-GoKIDNEY) P30DK114857. PVP is supported in part by R01DK106557.
Publisher Copyright:
© 2020 International Society of Nephrology
PY - 2020/7
Y1 - 2020/7
N2 - Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.
AB - Mitochondrial dysfunction is thought to be a critical pathway in the development and progression of kidney diseases, but optimal methods to assess kidney mitochondrial dysfunction are not well known. Saeki and colleagues use positron emission tomography imaging with a novel probe, 2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (18F-BCPP-BF), to visualize and assess kidney mitochondrial status. The authors demonstrate that reduced uptake of 18F-BCPP-BF, as assessed by positron emission tomography imaging, corresponds to reduced functioning mitochondria in 3 separate animal models of kidney diseases.
UR - http://www.scopus.com/inward/record.url?scp=85086398911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086398911&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2020.03.021
DO - 10.1016/j.kint.2020.03.021
M3 - Comment/debate
C2 - 32571489
AN - SCOPUS:85086398911
VL - 98
SP - 51
EP - 53
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 1
ER -