Visualizing structure and vascular interactions: Macular nonperfusion in three capillary plexuses

Justin J. Park; Christopher S. Chung; Amani A. Fawzi

doi:10.3928/23258160-20181101-16

Visualizing structure and vascular interactions: Macular nonperfusion in three capillary plexuses

Justin J. Park, Christopher S. Chung, Amani A. Fawzi^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses. RESULTS: Areas of decreased perfusion and capillary dropout on OCTA were found to be associated with three corresponding lesions on en face OCT: hyporeflectivity, cystic edema, and hard exudates. Vascular changes in individual capillary plexuses corresponded with structural changes in their respective perfused retinal layers. CONCLUSIONS: Using manual segmentation on OCTA, the authors provide a framework to visualize the relationship between vascular pathology on OCTA and structural changes on en face OCT within specific capillary plexuses.

Original language	English (US)
Pages (from-to)	E182-E190
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	49
Issue number	11
DOIs	https://doi.org/10.3928/23258160-20181101-16
State	Published - Nov 2018

Funding

Originally submitted November 30, 2017. Revision received November 30, 2017. Accepted for publication April 10, 2018. This work was partially supported by NIH/NIDDK 1DP3DK108248 (AAF) and the Illinois Society for the Prevention of Blindness, as well as research software and instrument support by Carl Zeiss Meditec. The authors report no relevant financial disclosures. Address correspondence to Amani Fawzi, MD, Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave., Suite 440, Chicago, IL 60611; email: [email protected]. doi: 10.3928/23258160-20181101-16 This work was partially supported by NIH/NIDDK 1DP3DK108248 (AAF) and the Illinois Society for the Prevention of Blindness, as well as research software and instrument support by Carl Zeiss Meditec.

ASJC Scopus subject areas

Ophthalmology
Surgery

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title = "Visualizing structure and vascular interactions: Macular nonperfusion in three capillary plexuses",

abstract = "BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses. RESULTS: Areas of decreased perfusion and capillary dropout on OCTA were found to be associated with three corresponding lesions on en face OCT: hyporeflectivity, cystic edema, and hard exudates. Vascular changes in individual capillary plexuses corresponded with structural changes in their respective perfused retinal layers. CONCLUSIONS: Using manual segmentation on OCTA, the authors provide a framework to visualize the relationship between vascular pathology on OCTA and structural changes on en face OCT within specific capillary plexuses.",

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Visualizing structure and vascular interactions: Macular nonperfusion in three capillary plexuses

Abstract

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