TY - JOUR
T1 - Visualizing structure and vascular interactions
T2 - Macular nonperfusion in three capillary plexuses
AU - Park, Justin J.
AU - Chung, Christopher S.
AU - Fawzi, Amani A.
N1 - Funding Information:
Originally submitted November 30, 2017. Revision received November 30, 2017. Accepted for publication April 10, 2018. This work was partially supported by NIH/NIDDK 1DP3DK108248 (AAF) and the Illinois Society for the Prevention of Blindness, as well as research software and instrument support by Carl Zeiss Meditec. The authors report no relevant financial disclosures. Address correspondence to Amani Fawzi, MD, Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave., Suite 440, Chicago, IL 60611; email: afawzimd@gmail.com. doi: 10.3928/23258160-20181101-16
Funding Information:
This work was partially supported by NIH/NIDDK 1DP3DK108248 (AAF) and the Illinois Society for the Prevention of Blindness, as well as research software and instrument support by Carl Zeiss Meditec.
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses. RESULTS: Areas of decreased perfusion and capillary dropout on OCTA were found to be associated with three corresponding lesions on en face OCT: hyporeflectivity, cystic edema, and hard exudates. Vascular changes in individual capillary plexuses corresponded with structural changes in their respective perfused retinal layers. CONCLUSIONS: Using manual segmentation on OCTA, the authors provide a framework to visualize the relationship between vascular pathology on OCTA and structural changes on en face OCT within specific capillary plexuses.
AB - BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses. RESULTS: Areas of decreased perfusion and capillary dropout on OCTA were found to be associated with three corresponding lesions on en face OCT: hyporeflectivity, cystic edema, and hard exudates. Vascular changes in individual capillary plexuses corresponded with structural changes in their respective perfused retinal layers. CONCLUSIONS: Using manual segmentation on OCTA, the authors provide a framework to visualize the relationship between vascular pathology on OCTA and structural changes on en face OCT within specific capillary plexuses.
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U2 - 10.3928/23258160-20181101-16
DO - 10.3928/23258160-20181101-16
M3 - Article
C2 - 30457654
AN - SCOPUS:85056736254
VL - 49
SP - E182-E190
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 11
ER -