TY - JOUR
T1 - Vitamin D-Dependent Rickets Type II
AU - Brooks, M. H.
AU - Stern, P. H.
AU - Bell, N. H.
PY - 1980/4/3
Y1 - 1980/4/3
N2 - To the Editor: We reported previously on a 22-year-old woman with hypocalcemia, secondary hyperparathyroidism, osteomalacia, osteitis fibrosa cystica, and marked elevation of serum 1,25-dihydroxyvitamin D.1 We termed this disorder vitamin D–dependent rickets Type II and have attributed the findings to impaired endorgan response to 1,25-dihydroxyvitamin D. Since that time several additional cases have been reported,2 , 3 including those of a brother and sister in whom the onset of the disease occurred in early childhood.3 The hypocalcemia and secondary hyperparathyroidism in our patient were corrected with vitamin D3, 4000 units per day for four weeks, but we were unable to.
AB - To the Editor: We reported previously on a 22-year-old woman with hypocalcemia, secondary hyperparathyroidism, osteomalacia, osteitis fibrosa cystica, and marked elevation of serum 1,25-dihydroxyvitamin D.1 We termed this disorder vitamin D–dependent rickets Type II and have attributed the findings to impaired endorgan response to 1,25-dihydroxyvitamin D. Since that time several additional cases have been reported,2 , 3 including those of a brother and sister in whom the onset of the disease occurred in early childhood.3 The hypocalcemia and secondary hyperparathyroidism in our patient were corrected with vitamin D3, 4000 units per day for four weeks, but we were unable to.
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U2 - 10.1056/NEJM198004033021416
DO - 10.1056/NEJM198004033021416
M3 - Letter
C2 - 7354819
AN - SCOPUS:0018834155
SN - 0028-4793
VL - 302
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 14
ER -