Vitamin D-Dependent Rickets Type II

M. H. Brooks, P. H. Stern, N. H. Bell

Research output: Contribution to journalLetterpeer-review

9 Scopus citations


To the Editor: We reported previously on a 22-year-old woman with hypocalcemia, secondary hyperparathyroidism, osteomalacia, osteitis fibrosa cystica, and marked elevation of serum 1,25-dihydroxyvitamin D.1 We termed this disorder vitamin D–dependent rickets Type II and have attributed the findings to impaired endorgan response to 1,25-dihydroxyvitamin D. Since that time several additional cases have been reported,2 , 3 including those of a brother and sister in whom the onset of the disease occurred in early childhood.3 The hypocalcemia and secondary hyperparathyroidism in our patient were corrected with vitamin D3, 4000 units per day for four weeks, but we were unable to.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 3 1980

ASJC Scopus subject areas

  • Medicine(all)


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