Vitamin D status and recurrent preterm birth

A nested case-control study in high-risk women

J. M. Thorp*, C. A. Camargo, P. L. McGee, M. Harper, M. A. Klebanoff, Y. Sorokin, M. W. Varner, R. J. Wapner, S. N. Caritis, J. D. Iams, M. W. Carpenter, Alan M Peaceman, B. M. Mercer, A. Sciscione, D. J. Rouse, S. M. Ramin, G. B. Anderson

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective To determine whether vitamin D status is associated with recurrent preterm birth, and any interactions between vitamin D levels and fish consumption. Design A nested case-control study, using data from a randomised trial of omega-3 fatty acid supplementation to prevent recurrent preterm birth. Setting Fourteen academic health centres in the USA. Population Women with prior spontaneous preterm birth. Methods In 131 cases (preterm delivery at <35 weeks of gestation) and 134 term controls, we measured serum 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography-tandem mass spectrometry (LC-MS) from samples collected at baseline (16-22 weeks of gestation). Logistic regression models controlled for study centre, maternal age, race/ethnicity, number of prior preterm deliveries, smoking status, body mass index, and treatment. Main outcome measures Recurrent preterm birth at <37 and <32 weeks of gestation. Results The median mid-gestation serum 25(OH)D concentration was 67 nmol/l, and 27% had concentrations of <50 nmol/l. Serum 25(OH)D concentration was not significantly associated with preterm birth (OR 1.33; 95% CI 0.48-3.70 for lowest versus highest quartiles). Likewise, comparing women with 25(OH)D concentrations of 50 nmol/l, or higher, with those with <50 nmol/l generated an odds ratio of 0.80 (95% CI 0.38-1.69). Contrary to our expectation, a negative correlation was observed between fish consumption and serum 25(OH)D concentration (-0.18, P < 0.01). Conclusions In a cohort of women with a prior preterm birth, vitamin D status at mid-pregnancy was not associated with recurrent preterm birth.

Original languageEnglish (US)
Pages (from-to)1617-1623
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume119
Issue number13
DOIs
StatePublished - Dec 1 2012

Fingerprint

Premature Birth
Vitamin D
Case-Control Studies
Pregnancy
Serum
Fishes
Logistic Models
Maternal Age
Omega-3 Fatty Acids
Tandem Mass Spectrometry
Liquid Chromatography
Body Mass Index
Smoking
Odds Ratio
Outcome Assessment (Health Care)
Health
Population

Keywords

  • Perinatal nutrition
  • preterm birth
  • vitamin D

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Thorp, J. M., Camargo, C. A., McGee, P. L., Harper, M., Klebanoff, M. A., Sorokin, Y., ... Anderson, G. B. (2012). Vitamin D status and recurrent preterm birth: A nested case-control study in high-risk women. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), 1617-1623. https://doi.org/10.1111/j.1471-0528.2012.03495.x
Thorp, J. M. ; Camargo, C. A. ; McGee, P. L. ; Harper, M. ; Klebanoff, M. A. ; Sorokin, Y. ; Varner, M. W. ; Wapner, R. J. ; Caritis, S. N. ; Iams, J. D. ; Carpenter, M. W. ; Peaceman, Alan M ; Mercer, B. M. ; Sciscione, A. ; Rouse, D. J. ; Ramin, S. M. ; Anderson, G. B. / Vitamin D status and recurrent preterm birth : A nested case-control study in high-risk women. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2012 ; Vol. 119, No. 13. pp. 1617-1623.
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abstract = "Objective To determine whether vitamin D status is associated with recurrent preterm birth, and any interactions between vitamin D levels and fish consumption. Design A nested case-control study, using data from a randomised trial of omega-3 fatty acid supplementation to prevent recurrent preterm birth. Setting Fourteen academic health centres in the USA. Population Women with prior spontaneous preterm birth. Methods In 131 cases (preterm delivery at <35 weeks of gestation) and 134 term controls, we measured serum 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography-tandem mass spectrometry (LC-MS) from samples collected at baseline (16-22 weeks of gestation). Logistic regression models controlled for study centre, maternal age, race/ethnicity, number of prior preterm deliveries, smoking status, body mass index, and treatment. Main outcome measures Recurrent preterm birth at <37 and <32 weeks of gestation. Results The median mid-gestation serum 25(OH)D concentration was 67 nmol/l, and 27{\%} had concentrations of <50 nmol/l. Serum 25(OH)D concentration was not significantly associated with preterm birth (OR 1.33; 95{\%} CI 0.48-3.70 for lowest versus highest quartiles). Likewise, comparing women with 25(OH)D concentrations of 50 nmol/l, or higher, with those with <50 nmol/l generated an odds ratio of 0.80 (95{\%} CI 0.38-1.69). Contrary to our expectation, a negative correlation was observed between fish consumption and serum 25(OH)D concentration (-0.18, P < 0.01). Conclusions In a cohort of women with a prior preterm birth, vitamin D status at mid-pregnancy was not associated with recurrent preterm birth.",
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Thorp, JM, Camargo, CA, McGee, PL, Harper, M, Klebanoff, MA, Sorokin, Y, Varner, MW, Wapner, RJ, Caritis, SN, Iams, JD, Carpenter, MW, Peaceman, AM, Mercer, BM, Sciscione, A, Rouse, DJ, Ramin, SM & Anderson, GB 2012, 'Vitamin D status and recurrent preterm birth: A nested case-control study in high-risk women', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 119, no. 13, pp. 1617-1623. https://doi.org/10.1111/j.1471-0528.2012.03495.x

Vitamin D status and recurrent preterm birth : A nested case-control study in high-risk women. / Thorp, J. M.; Camargo, C. A.; McGee, P. L.; Harper, M.; Klebanoff, M. A.; Sorokin, Y.; Varner, M. W.; Wapner, R. J.; Caritis, S. N.; Iams, J. D.; Carpenter, M. W.; Peaceman, Alan M; Mercer, B. M.; Sciscione, A.; Rouse, D. J.; Ramin, S. M.; Anderson, G. B.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 119, No. 13, 01.12.2012, p. 1617-1623.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D status and recurrent preterm birth

T2 - A nested case-control study in high-risk women

AU - Thorp, J. M.

AU - Camargo, C. A.

AU - McGee, P. L.

AU - Harper, M.

AU - Klebanoff, M. A.

AU - Sorokin, Y.

AU - Varner, M. W.

AU - Wapner, R. J.

AU - Caritis, S. N.

AU - Iams, J. D.

AU - Carpenter, M. W.

AU - Peaceman, Alan M

AU - Mercer, B. M.

AU - Sciscione, A.

AU - Rouse, D. J.

AU - Ramin, S. M.

AU - Anderson, G. B.

PY - 2012/12/1

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N2 - Objective To determine whether vitamin D status is associated with recurrent preterm birth, and any interactions between vitamin D levels and fish consumption. Design A nested case-control study, using data from a randomised trial of omega-3 fatty acid supplementation to prevent recurrent preterm birth. Setting Fourteen academic health centres in the USA. Population Women with prior spontaneous preterm birth. Methods In 131 cases (preterm delivery at <35 weeks of gestation) and 134 term controls, we measured serum 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography-tandem mass spectrometry (LC-MS) from samples collected at baseline (16-22 weeks of gestation). Logistic regression models controlled for study centre, maternal age, race/ethnicity, number of prior preterm deliveries, smoking status, body mass index, and treatment. Main outcome measures Recurrent preterm birth at <37 and <32 weeks of gestation. Results The median mid-gestation serum 25(OH)D concentration was 67 nmol/l, and 27% had concentrations of <50 nmol/l. Serum 25(OH)D concentration was not significantly associated with preterm birth (OR 1.33; 95% CI 0.48-3.70 for lowest versus highest quartiles). Likewise, comparing women with 25(OH)D concentrations of 50 nmol/l, or higher, with those with <50 nmol/l generated an odds ratio of 0.80 (95% CI 0.38-1.69). Contrary to our expectation, a negative correlation was observed between fish consumption and serum 25(OH)D concentration (-0.18, P < 0.01). Conclusions In a cohort of women with a prior preterm birth, vitamin D status at mid-pregnancy was not associated with recurrent preterm birth.

AB - Objective To determine whether vitamin D status is associated with recurrent preterm birth, and any interactions between vitamin D levels and fish consumption. Design A nested case-control study, using data from a randomised trial of omega-3 fatty acid supplementation to prevent recurrent preterm birth. Setting Fourteen academic health centres in the USA. Population Women with prior spontaneous preterm birth. Methods In 131 cases (preterm delivery at <35 weeks of gestation) and 134 term controls, we measured serum 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography-tandem mass spectrometry (LC-MS) from samples collected at baseline (16-22 weeks of gestation). Logistic regression models controlled for study centre, maternal age, race/ethnicity, number of prior preterm deliveries, smoking status, body mass index, and treatment. Main outcome measures Recurrent preterm birth at <37 and <32 weeks of gestation. Results The median mid-gestation serum 25(OH)D concentration was 67 nmol/l, and 27% had concentrations of <50 nmol/l. Serum 25(OH)D concentration was not significantly associated with preterm birth (OR 1.33; 95% CI 0.48-3.70 for lowest versus highest quartiles). Likewise, comparing women with 25(OH)D concentrations of 50 nmol/l, or higher, with those with <50 nmol/l generated an odds ratio of 0.80 (95% CI 0.38-1.69). Contrary to our expectation, a negative correlation was observed between fish consumption and serum 25(OH)D concentration (-0.18, P < 0.01). Conclusions In a cohort of women with a prior preterm birth, vitamin D status at mid-pregnancy was not associated with recurrent preterm birth.

KW - Perinatal nutrition

KW - preterm birth

KW - vitamin D

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