Vitamin E isoforms as modulators of lung inflammation

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.

Original languageEnglish (US)
Pages (from-to)4347-4363
Number of pages17
JournalNutrients
Volume5
Issue number11
DOIs
StatePublished - Oct 31 2013

Keywords

  • Endothelial
  • Lung disease
  • Tocopherols

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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