Abstract
The autoimmune condition vitiligo, characterized by skin depigmentation, presents challenges for effective treatment design, with Janus kinase (JAK) inhibitors and other repurposed drugs offering a promising strategy for symptom management. This review explores advantages and shortcomings of current therapies, while presenting the urgent need for further innovative approaches. We emphasize the growing understanding of autoimmune involvement in vitiligo, highlighting several novel treatment avenues including relieving melanocyte stress, preventing dendritic cell activation, halting T cell migration, and suppressing inflammation and autoimmunity. Integrating psychodrama therapy to remediate stress alongside medical interventions marks a holistic approach to enhance patient well-being. The molecular underpinnings of vitiligo care are covered, emphasizing exciting advances revolutionizing vitiligo treatment and improving the quality of life for affected individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 844-862 |
| Number of pages | 19 |
| Journal | Trends in Molecular Medicine |
| Volume | 30 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2024 |
Funding
This research has been funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (Grant No. AP13068072 ) to Z.M. and Leo Foundation Research Award LF-OC-23-001288 to I.C.L.P. We also would like to thank members of the global vitiligo foundation for supporting the cause of vitiligo patients and the treatments available to them.
Keywords
- autoimmunity
- skin
- therapy
- vitiligo
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology