Abstract
Whole cell voltage-clamp recording were made from cultured rat neostriatal neurons. Depolarizing voltage commands evoked transient and sustained outward K-currents. The transient K-current was activated by depolarizing commands beyond -50 mV; peak current was dependent upon holding potential. Bath application of 4-aminopyridine, but not inorganic calcium channel blockers (Cd, Co, Mn), attenuated the transient current. Reversal was near the K-equilibrium potential. These properties suggest that this transient K-current is similar to the A-current described in a number of other neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-192 |
| Number of pages | 6 |
| Journal | Brain research |
| Volume | 473 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 8 1988 |
Keywords
- A-current
- Cell culture
- Neostriatum
- Voltage-clamp
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Surmeier, D. J., Bargas, J., & Kitai, S. T. (1988). Voltage-clamp analysis of a transient potassium current in rat neostriatal neurons. Brain research, 473(1), 187-192. https://doi.org/10.1016/0006-8993(88)90334-4