Voltage-clamp analysis of a transient potassium current in rat neostriatal neurons

D. James Surmeier*, Jose Bargas, S. T. Kitai

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Whole cell voltage-clamp recording were made from cultured rat neostriatal neurons. Depolarizing voltage commands evoked transient and sustained outward K-currents. The transient K-current was activated by depolarizing commands beyond -50 mV; peak current was dependent upon holding potential. Bath application of 4-aminopyridine, but not inorganic calcium channel blockers (Cd, Co, Mn), attenuated the transient current. Reversal was near the K-equilibrium potential. These properties suggest that this transient K-current is similar to the A-current described in a number of other neurons.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalBrain research
Volume473
Issue number1
DOIs
StatePublished - Nov 8 1988

Keywords

  • A-current
  • Cell culture
  • Neostriatum
  • Voltage-clamp

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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