Voltage-dependent removal of sodium inactivation by N-bromoacetamide and pronase

V. L. Salgado*, J. Z. Yeh, T. Narahashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

When perfused internally through crayfish giant axons, pronase removed sodium inactivation more than three times as fast at -100 mV as compared with -30 mV. N-bromoacetamide, applied internally, removed sodium inactivation twice as fast at -100 mV as at -30 mV, and the relative rate of removal declined with membrane depolarization in proportion to steady-state sodium inactivation. We conclude that in the closed conformation the sodium inactivation gate is partially protected from destruction by N-bromoacetamide and pronase.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
JournalBiophysical Journal
Volume47
Issue number4
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Biophysics

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