Voltage-sensitive calcium channels and calcium antagonists

T. J. Kamp, R. J. Miller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Voltage-sensitive Ca channels (VSCC) have been characterized by use of electrophysiological techniques, and multiple distinct types of VSCC have been demonstrated. One type of VSCC (L type) appears to be the main site of action of the Ca antagonist drugs. These compounds are currently employed in the treatment of a variety of cardiovascular disorders. Radiolabeled Ca antagonists have revealed the presence of distinct receptors for these compounds in a wide range of tissues. Radiolabeled Ca antagonists have also been used to biochemically isolate one type of VSCC and identify it as a multisubunit glycoprotein.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalISI Atlas of Science: Pharmacology
Volume1
Issue number2
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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