Abstract
Objectives: To test the feasibility of four-dimensional (4D) flow MRI to quantify the systolic wall shear stress (WSSsystole) and oscillatory shear index (OSI) in high-grade internal carotid artery (ICA) stenosis before and after endarterectomy (CEA). Methods: Twenty patients with ≥60 % ICA stenosis were prospectively and consequently included. Four-dimensional flow MRI was used to measure individual time-resolved 3D blood flow velocities. Segmental WSSsystole and OSI were derived at eight wall segments in analysis planes positioned along the ICA, common (CCA) and external carotid artery (ECA). Results: Regional WSSsystole of all patients decreased after CEA (P < 0.05). Changes were most prominent at the ICA bulb but remained unchanged in the CCA and ECA. OSI was significantly lower after CEA in the lateral vessel walls (P < 0.05). For analysis planes at the stenosis in- and outlet, a reduction of mean WSSsystole by 32 % and 52 % (P < 0.001) and OSI distal to the stenosis (40 %, P = 0.01) was found after CEA. Conclusions: Our findings show the potential of in vivo 4D flow MRI to quantify haemodynamic changes in wall shear stress even in patients with complex flow conditions. Key Points: • The 4D flow MRI allows in vivo measurement of individual 3D blood flow. • Regional wall shear stress can be derived from such 3D flow data. • Even complex flow in high-grade internal carotid artery stenosis can be analysed. • This technique could be valuable for future studies of carotid atherosclerosis.
Original language | English (US) |
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Pages (from-to) | 3361-3369 |
Number of pages | 9 |
Journal | European Radiology |
Volume | 23 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2013 |
Keywords
- 4D flow MRI
- Atherosclerosis
- Carotid
- Endarterectomy
- Wall shear stress
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging