Warfarin-induced factor VII deficiency and the bleeding time

David Green*, Chung hsin Ts'ao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The effect of warfarin-induced factor VII deficiency on the skin bleeding time was investigated in 10 consecutive patients with mean prothrombin times of 33 sec and factor VII levels of 7%. Bleeding times in all but one subject were entirely within the normal range. We conclude that warfarin administration, even to the point of prolonging the prothrombin time beyond the therapeutic range, is not associated with an abnormal bleeding time. Furthermore, from the above evidence and a review of the literature, it is considered doubtful that factor VII plays a major role in primary hemostasis.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalThrombosis Research
Issue number4
StatePublished - Feb 15 1983


  • Bleeding time
  • factor VII deficiency
  • primary hemostasis

ASJC Scopus subject areas

  • Hematology


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