Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes; Navdeep S. Chandel

doi:10.1016/j.cmet.2017.11.005

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes, Navdeep S. Chandel^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Short survey › peer-review

46 Scopus citations

Abstract

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors. Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. and Faubert et al. demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

Original language	English (US)
Pages (from-to)	803-804
Number of pages	2
Journal	Cell Metabolism
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2017.11.005
State	Published - Dec 5 2017

Funding

N.S.C. is supported by NIH 5R35CA197532-02 , 5P01AG049665 , and 5P01HL071643-13 . We thank the DeBerardinis lab and Aron Jaffe for helpful discussions. B.F. is supported by the Canadian Institutes of Health Research ( MFE 140911 ). J.K. is supported by an American Lung Association Fellowship ( RT-306212 ). J.D.Y. is supported by NIH grant R01 DK106348 . R.J.D. is supported by grants from the NIH ( R35CA220449 ), Howard Hughes Medical Institute (Faculty Scholars Program, grant 55108514 ), the Welch Foundation ( I-1733 ), and the V Foundation (Translational Award). We acknowledge support from NIH grants P50 CA70907 , P41 EB015908 , and UL1 TR001105 and from the UT Southwestern Small Animal Imaging Resource, which is supported in part through an NCI Cancer Center Support Grant ( 1P30 CA142543-01 ). R.E.L. is the recipient of a research grant from Philips Healthcare . R.J.D. is an advisor for Agios Pharmaceuticals.

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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title = "Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle",

abstract = "Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors. Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. and Faubert et al. demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.",

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AB - Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors. Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. and Faubert et al. demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

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Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

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