Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle

Inmaculada Martínez-Reyes, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations

Abstract

Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors. Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. and Faubert et al. demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.

Original languageEnglish (US)
Pages (from-to)803-804
Number of pages2
JournalCell Metabolism
Volume26
Issue number6
DOIs
StatePublished - Dec 5 2017

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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