Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry

Geoffray Leriche; Arash Manafirad; Steven Nguyen; Nia Bell; Joseph P. Patterson; S. Thayumanavan; Jerry Yang; Anthony D. Dinsmore; Nathan C. Gianneschi

doi:10.1021/acs.chemmater.8b00992

Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry

Geoffray Leriche, Arash Manafirad, Steven Nguyen, Nia Bell, Joseph P. Patterson, S. Thayumanavan, Jerry Yang, Anthony D. Dinsmore^*, Nathan C. Gianneschi

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Researchers report the synthesis of a new archaea-inspired tetraether lipid and study the mechanical elastic properties of membranes made from this bolalipid. To access structural diversity in the hydrophobic moiety of the lipids and to tune membrane properties, they have used used Huisgen 1,3-dipolar cycloaddition strategy to design and synthesize a tetraether lipid incorporating phytanyl side chains and polar 1,4 triazole rings known to change lipid packing. The researchers demonstrate the first example of the synthesis of phytanyl side chain incorporated tetraether lipids with 1,4-triazole rings. They also confirm the ability of lipids incorporating 1,4-triazole rings to form stable small and giant vesicles and examined their physical and mechanical properties using a micropipette aspiration technique.

Original language	English (US)
Pages (from-to)	3618-3622
Number of pages	5
Journal	Chemistry of Materials
Volume	30
Issue number	11
DOIs	https://doi.org/10.1021/acs.chemmater.8b00992
State	Published - Jun 12 2018

Funding

*N. C. Gianneschi. E-mail: nathan.gianneschi@northwestern. edu. *A. D. Dinsmore. E-mail: [email protected]. *S. Thayumanavan. E-mail: [email protected]. ORCID S. Thayumanavan: 0000-0002-6475-6726 Jerry Yang: 0000-0002-8423-7376 Anthony D. Dinsmore: 0000-0002-0677-765X Nathan C. Gianneschi: 0000-0001-9945-5475 Author Contributions ⊥These authors contributed equally. Funding This work was supported by the Air Force Office of Scientific Research (FA9550-12-1-0435) and the U.S. Army Research Office (W911NF-15-1-0568). Notes The authors declare no competing financial interest.

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Materials Chemistry

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10.1021/acs.chemmater.8b00992

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title = "Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry",

abstract = "Researchers report the synthesis of a new archaea-inspired tetraether lipid and study the mechanical elastic properties of membranes made from this bolalipid. To access structural diversity in the hydrophobic moiety of the lipids and to tune membrane properties, they have used used Huisgen 1,3-dipolar cycloaddition strategy to design and synthesize a tetraether lipid incorporating phytanyl side chains and polar 1,4 triazole rings known to change lipid packing. The researchers demonstrate the first example of the synthesis of phytanyl side chain incorporated tetraether lipids with 1,4-triazole rings. They also confirm the ability of lipids incorporating 1,4-triazole rings to form stable small and giant vesicles and examined their physical and mechanical properties using a micropipette aspiration technique.",

author = "Geoffray Leriche and Arash Manafirad and Steven Nguyen and Nia Bell and Patterson, {Joseph P.} and S. Thayumanavan and Jerry Yang and Dinsmore, {Anthony D.} and Gianneschi, {Nathan C.}",

note = "Funding Information: *N. C. Gianneschi. E-mail: nathan.gianneschi@northwestern. edu. *A. D. Dinsmore. E-mail: [email protected]. *S. Thayumanavan. E-mail: [email protected]. ORCID S. Thayumanavan: 0000-0002-6475-6726 Jerry Yang: 0000-0002-8423-7376 Anthony D. Dinsmore: 0000-0002-0677-765X Nathan C. Gianneschi: 0000-0001-9945-5475 Author Contributions ⊥These authors contributed equally. Funding This work was supported by the Air Force Office of Scientific Research (FA9550-12-1-0435) and the U.S. Army Research Office (W911NF-15-1-0568). Notes The authors declare no competing financial interest.",

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AU - Patterson, Joseph P.

AU - Thayumanavan, S.

AU - Yang, Jerry

AU - Dinsmore, Anthony D.

AU - Gianneschi, Nathan C.

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Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry

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