TY - JOUR
T1 - Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry
AU - Leriche, Geoffray
AU - Manafirad, Arash
AU - Nguyen, Steven
AU - Bell, Nia
AU - Patterson, Joseph P.
AU - Thayumanavan, S.
AU - Yang, Jerry
AU - Dinsmore, Anthony D.
AU - Gianneschi, Nathan C.
N1 - Funding Information:
*N. C. Gianneschi. E-mail: nathan.gianneschi@northwestern. edu. *A. D. Dinsmore. E-mail: dinsmore@physics.umass.edu. *S. Thayumanavan. E-mail: thai@chem.umass.edu. ORCID S. Thayumanavan: 0000-0002-6475-6726 Jerry Yang: 0000-0002-8423-7376 Anthony D. Dinsmore: 0000-0002-0677-765X Nathan C. Gianneschi: 0000-0001-9945-5475 Author Contributions ⊥These authors contributed equally. Funding This work was supported by the Air Force Office of Scientific Research (FA9550-12-1-0435) and the U.S. Army Research Office (W911NF-15-1-0568). Notes The authors declare no competing financial interest.
PY - 2018/6/12
Y1 - 2018/6/12
N2 - Researchers report the synthesis of a new archaea-inspired tetraether lipid and study the mechanical elastic properties of membranes made from this bolalipid. To access structural diversity in the hydrophobic moiety of the lipids and to tune membrane properties, they have used used Huisgen 1,3-dipolar cycloaddition strategy to design and synthesize a tetraether lipid incorporating phytanyl side chains and polar 1,4 triazole rings known to change lipid packing. The researchers demonstrate the first example of the synthesis of phytanyl side chain incorporated tetraether lipids with 1,4-triazole rings. They also confirm the ability of lipids incorporating 1,4-triazole rings to form stable small and giant vesicles and examined their physical and mechanical properties using a micropipette aspiration technique.
AB - Researchers report the synthesis of a new archaea-inspired tetraether lipid and study the mechanical elastic properties of membranes made from this bolalipid. To access structural diversity in the hydrophobic moiety of the lipids and to tune membrane properties, they have used used Huisgen 1,3-dipolar cycloaddition strategy to design and synthesize a tetraether lipid incorporating phytanyl side chains and polar 1,4 triazole rings known to change lipid packing. The researchers demonstrate the first example of the synthesis of phytanyl side chain incorporated tetraether lipids with 1,4-triazole rings. They also confirm the ability of lipids incorporating 1,4-triazole rings to form stable small and giant vesicles and examined their physical and mechanical properties using a micropipette aspiration technique.
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U2 - 10.1021/acs.chemmater.8b00992
DO - 10.1021/acs.chemmater.8b00992
M3 - Article
AN - SCOPUS:85048429473
VL - 30
SP - 3618
EP - 3622
JO - Chemistry of Materials
JF - Chemistry of Materials
SN - 0897-4756
IS - 11
ER -