WDR5, a complexed protein

Raymond C. Trievel, Ali Shilatifard

Research output: Contribution to journalComment/debatepeer-review

108 Scopus citations


The WD40 protein WDR5 is a core subunit of the human MLL and SET1 (hCOMPASS) histone H3 Lys4 (H3K4) methyltransferase complexes. Although initial studies suggested that WDR5 interacts with methylated H3K4 to catalyze Lys4 trimethylation, recent work has revealed that it binds an arginine-bearing motif in MLL1, promoting complex assembly and activity. These findings suggest that WDR5 functions as a peptidyl arginine recognition factor that facilitates the assembly of hCOMPASS and other chromatin-modifying complexes.

Original languageEnglish (US)
Pages (from-to)678-680
Number of pages3
JournalNature Structural and Molecular Biology
Issue number7
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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