Abstract
The ability to identify and transform selectively similar constitutional fragments in molecules in a predetermined direction over all other possible directions remains a fundamental challenge in relation to the growth and reach of synthetic chemistry. A rapidly emerging approach toward this goal is to leverage weak bonding interactions, including both noncovalent and dynamic covalent bonds to control regio- and site selectivities. Drawing inspiration from the reactions catalyzed by enzymes, chemists have developed a wide variety of weak bonding strategies to facilitate regio- and site-selective transformations without the need to introduce additional handles onto molecular frameworks. Here, by classifying these weak bonding protocols into four categories, namely, bond-destabilizing, masking, pre-organizing, and templating strategies, we summarize the advances that have been made during the past two decades, highlighting their relative simplicity in promoting regio- and site-selective reactions that would otherwise be difficult to perform on molecules.
Original language | English (US) |
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Pages (from-to) | 414-438 |
Number of pages | 25 |
Journal | Chem |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - Feb 10 2022 |
Keywords
- SDG12: Responsible consumption and production
- SDG3: Good health and well-being
- dynamic covalent bonds
- host-guest chemistry
- nanoconfinement
- noncovalent bonding interactions
- pre-organization
- regioselectivity
- supramolecular catalysis
ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry
- Environmental Chemistry
- Chemical Engineering(all)
- Biochemistry, medical
- Materials Chemistry