Weaker top-down modulation from the left inferior frontal gyrus in children

Tali Bitan*, Douglas D. Burman, Dong Lu, Nadia E. Cone, Darren R. Gitelman, Marek-Marsel Mesulam, James R. Booth

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Previous studies have shown that developmental changes in the structure and function of prefrontal regions can continue throughout childhood and adolescence. Our recent results suggested a role for the left inferior frontal cortex in modulating task-dependent shifts in effective connectivity when adults focus on orthographic versus phonological aspects of presented words. Specifically, the top-down influence of the inferior frontal cortex determined whether incoming word-form information from the fusiform gyrus would have a greater impact on the parietal areas involved in orthographic processing or temporal areas involved in phonological processing (Bitan, T., Booth, J.R., Choy, J., Burman, D.D., Gitelman, D.R. and Mesulam, M.-M., 2005. Shifts of Effective Connectivity within a Language Network during Rhyming and Spelling. J. Neurosci. 25, 5397-5403.). In the current study, we find that children displayed an identical pattern of task-dependent functional activations within this network. In comparison to adults, however, children had significantly weaker top-down modulatory influences emanating from the inferior frontal area. Adult language processing may thus involve greater top-down cognitive control compared to children, resulting in less interference from task-irrelevant information.

Original languageEnglish (US)
Pages (from-to)991-998
Number of pages8
JournalNeuroImage
Volume33
Issue number3
DOIs
StatePublished - Nov 15 2006

Keywords

  • Development
  • Effective connectivity
  • Orthography
  • Phonology
  • Reading
  • fMRI

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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    Bitan, T., Burman, D. D., Lu, D., Cone, N. E., Gitelman, D. R., Mesulam, M-M., & Booth, J. R. (2006). Weaker top-down modulation from the left inferior frontal gyrus in children. NeuroImage, 33(3), 991-998. https://doi.org/10.1016/j.neuroimage.2006.07.007