Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy

Daphne Y. Xiao; Suhong Luo; Katiuscia O’Brian; Weijian Liu; Kenneth R. Carson

doi:10.1080/10428194.2016.1217526

Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy

Daphne Y. Xiao, Suhong Luo, Katiuscia O’Brian, Weijian Liu, Kenneth R. Carson^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.

Original language	English (US)
Pages (from-to)	851-858
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	58
Issue number	4
DOIs	https://doi.org/10.1080/10428194.2016.1217526
State	Published - Apr 3 2017

Funding

This work was supported by: The NCCN Young Investigator Awards (YIA), The Barnes-Jewish Hospital Foundation, The American Cancer Society [MSRG-13-077-01-CPHPS], the National Cancer Institute at the National Institutes of Health [U54CA155496 and 5K12HL087107], and the Washington University Institute of Clinical and Translational Sciences grant [UL1TR000448, sub-award TL1TR000449], from the National Center for Advancing Translational Sciences of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of: The United States Department of Veterans Affairs, the National Cancer Institute, or the National Institutes of Health.

Keywords

Body weight changes
lymphoma
veterans

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428194.2016.1217526

Cite this

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title = "Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy",

abstract = "Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.",

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note = "Funding Information: This work was supported by: The NCCN Young Investigator Awards (YIA), The Barnes-Jewish Hospital Foundation, The American Cancer Society [MSRG-13-077-01-CPHPS], the National Cancer Institute at the National Institutes of Health [U54CA155496 and 5K12HL087107], and the Washington University Institute of Clinical and Translational Sciences grant [UL1TR000448, sub-award TL1TR000449], from the National Center for Advancing Translational Sciences of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of: The United States Department of Veterans Affairs, the National Cancer Institute, or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2016 Informa UK Limited, trading as Taylor & Francis Group.",

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N1 - Funding Information: This work was supported by: The NCCN Young Investigator Awards (YIA), The Barnes-Jewish Hospital Foundation, The American Cancer Society [MSRG-13-077-01-CPHPS], the National Cancer Institute at the National Institutes of Health [U54CA155496 and 5K12HL087107], and the Washington University Institute of Clinical and Translational Sciences grant [UL1TR000448, sub-award TL1TR000449], from the National Center for Advancing Translational Sciences of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of: The United States Department of Veterans Affairs, the National Cancer Institute, or the National Institutes of Health. Publisher Copyright: © 2016 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2017/4/3

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N2 - Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.

AB - Understanding weight change patterns in follicular lymphoma (FL) may be important for the assessment of prognosis as well as the long-term care of survivors. A retrospective cohort of United States veterans with a new diagnosis of FL between October 1, 1998 and September 30, 2010 was assembled. Weight changes were evaluated before, during, and after treatment in 896 FL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP ± R); cyclophosphamide, vincristine, and prednisone, with or without rituximab (CVP ± R); or rituximab monotherapy. Weight decreased an average of 1.4 kg during therapy, and >5% weight loss during this time period was associated with worse overall survival. Weight increased to an average of 1.4 kg above baseline by 24 months after treatment initiation, with 15% gaining greater than 10% of their baseline weight. Weight management strategies may be an important part of long-term survivorship planning.

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Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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