Weight gain and withdrawal symptoms after smoking cessation: a preventive intervention using d-fenfluramine.

B. Spring*, J. Wurtman, R. Gleason, R. Wurtman, K. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Directly measured food intake in 31 overweight female smokers to test whether (a) calorie and carbohydrate intakes increase after smoking cessation and (b) double-blind d-fenfluramine (30 mg), a serotonin-releasing drug, suppresses weight gain, overeating, and dysphoric mood associated with stopping smoking. Placebo-treated patients grew dysphoric after smoking withdrawal and ate 300 kcal/day more from 2 to 28 days after, showing a 3.5-lb weight gain. Fat and protein intakes did not change, but carbohydrate intake increased (30% to 40%). D-fenfluramine prevented postcessation dysphoria. Although drug-treated patients ate more carbohydrate snacks just after quitting, they returned to baseline by 4 weeks, showing a 1.8-lb weight loss. Agents that enhance brain serotonin-mediated neurotransmission may help prevent weight gain, overeating, and dysphoric mood after smoking withdrawal.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalHealth psychology : official journal of the Division of Health Psychology, American Psychological Association
Volume10
Issue number3
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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