Weight loss surgery improves quality of life in pediatric patients with osteogenesis imperfecta

Augusto Zani, Martha Ford-Adams, Megan Ratcliff, Denise Bevan, Thomas H. Inge, Ashish Desai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background Osteogenesis imperfecta (OI) is an inherited disorder, which causes brittle bones resulting in recurrent fractures. The associated poor mobility of children with OI increases susceptibility to obesity, and obesity further dramatically limits mobility and increases fracture risk. Objectives The aim of this report is to describe outcomes of weight loss surgery (WLS) in 2 adolescents with severe obesity and OI. Setting Two University Hospitals (in the United Kingdom and in the United States). Methods Two cases of OI treated with WLS were identified. Pre- and postoperative anthropometric and biochemical data and clinical course were reviewed. Results In these 2 cases, preoperative Body Mass Index (BMI) values were 38 and 46 kg/m2. Following laparoscopic sleeve gastrectomy (LSG), BMI decreased by 55% and 60% by 26 and 24 months, respectively. There were no surgical complications, and both patients experienced improvement in their mobility and ability to perform activities of daily living. Conclusion WLS effectively treated severe obesity in 2 OI patients and substantially improved mobility and quality of life, theoretically reducing fracture risk.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalSurgery for Obesity and Related Diseases
Issue number1
StatePublished - Jan 1 2017
Externally publishedYes


  • Brittle bone
  • Child
  • Laparoscopic
  • Obesity
  • Osteogenesis imperfecta
  • Pediatric
  • Quality of life
  • Sleeve gastrectomy
  • Weight loss surgery

ASJC Scopus subject areas

  • Surgery


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