West Nile virus encephalomyelitis with polio-like paralysis & nigral degeneration

Kristian T. Schafernak, Eileen H. Bigio*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: Patients infected with West Nile virus (WNV) may develop acute neurologic disease, which can be severe or even fatal, including WNV meningitis, encephalitis, and an irreversible acute flaccid paralysis or poliomyelitis-like syndrome. Movement disorders have also been described. Report: We report combined neuronal loss, gliosis, and neurofibrillary tangle formation in the substantia nigra of a 41-year-old man with a history of WNV encephalomyelitis and poliomyelitis-like paralysis. Conclusions: Clinically our patient did not display parkinsonism, however, it is interesting to speculate whether, in the absence of the residual subacute poliomyelitis-like syndrome, the neuropathologic findings could have eventually evolved clinically into WNV-associated post-encephalitic parkinsonism.

Original languageEnglish (US)
Pages (from-to)407-410
Number of pages4
JournalCanadian Journal of Neurological Sciences
Issue number4
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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