TY - JOUR
T1 - What changes in inflammatory bowel disease management can be implemented today?
AU - Louis, Edouard
AU - Baumgart, Daniel C.
AU - Ghosh, Subrata
AU - Gomollón, Fernando
AU - Hanauer, Stephen
AU - Hart, Ailsa
AU - Irving, Peter
N1 - Funding Information:
Professor Ghosh has received speaker and consultancy fees from MSD, Ferring, Centocor, Abbott Laboratories, Shire Pharmaceuti- cals. Professor Ghosh has acted as scientific consultant for Pfizer, MSD, Centocor, BMS, Abbott Laboratories and received research grants from Schering Plough and Abbott Laboratories.
Funding Information:
Professor Louis has received consultancy fees from Abbott Laboratories, MSD, Ferring, Millenium, Schering Plough, Shire Pharmaceuticals and UCB. He has received speaker fees from Abbott Laboratories, Astra Zeneca, Falk, Ferring, MSD and Schering Plough; and has received payment for development of educational presentations from Abbott Laboratories. Professor Louis has received research grants from Abbott Laboratories, AstraZeneca, MSD and Schering Plough.
Funding Information:
This paper is part of a supplement published with financial support from Abbott.
Funding Information:
Professor Baumgart does declare the following the following conflicts of interest that are relevant to inflammatory bowel disease. Research support: Abbott, Astellas (formerly Fujisawa), Biocodex, Facet Biotech (formerly Protein Design Labs) and Shire. Consultant: Abbott, AstraZeneca, Bayer Schering Pharma (BSP), Cellerix, (TiGenix), Genentech (Roche group), medac autoimmun, MSD (formerly essex), Otsuka, Facet Biotech, (formerly Protein Design Labs), UCB. Lecture Fees: Abbott, AstraZeneca, Dr. Falk Pharma, Ferring, MSD (formerly essex pharma), Otsuka, Shire, UCB. All of his activities and contracts are in conformity with the “FSA-Kodex Fachkreise” (voluntary self-monitoring code for expert consultants to the pharmaceutical industry), have been checked by the legal Department of Charité Universitätsmedizin, Berlin, and have been approved by the directorate of the Faculty of Medicine Charité Universitätsmedizin Berlin. Professor Baumgart’s research group received grant support from the Eli & Edythe L. Broad Foundation, Los Angeles, CA, USA, Fritz Bender Foundation, Munich, Germany, German Research Council (DFG), Bonn, Germany, the German Federal Ministry of Education and Research (BMBF), the Volkswagen Foundation (VolkswagenStiftung), the BMW Foundation, the United European Gastroenterology Federation (UEGF), and continuous intramural Charité Medical School bonus funding.
PY - 2012/2
Y1 - 2012/2
N2 - Innovative ideas are required to improve the management of inflammatory bowel disease and to share best practice that can be implemented into clinical practice today. The use of biomarkers such as calprotectin to monitor disease progression and treatment response could help to improve management of inflammatory bowel disease, but several strategies need to be implemented to make this a reality in clinical practice. The use of calprotectin as a biomarker and the manipulation of the thiopurine pathway to extend the use of current therapies are examples of how basic research can translate into patient benefit. Translational research into the use of microbiota and predictive factors for response and toxicity to drugs, may provide future clinical applications. Global improvement in care in inflammatory bowel disease could also be advanced by improving service provision. For example, the establishment of 'Centres of Excellence', a global interactive inflammatory disease map, and the alignment of processes and standards of care within treatment centres may help to achieve better outcomes for patients with inflammatory bowel disease. Realization of this goal, as well as a better understanding of the aetiology of the disease, may be furthered by collaborative efforts between organizations involved in inflammatory bowel disease as well as wider collaboration across countries and globally.
AB - Innovative ideas are required to improve the management of inflammatory bowel disease and to share best practice that can be implemented into clinical practice today. The use of biomarkers such as calprotectin to monitor disease progression and treatment response could help to improve management of inflammatory bowel disease, but several strategies need to be implemented to make this a reality in clinical practice. The use of calprotectin as a biomarker and the manipulation of the thiopurine pathway to extend the use of current therapies are examples of how basic research can translate into patient benefit. Translational research into the use of microbiota and predictive factors for response and toxicity to drugs, may provide future clinical applications. Global improvement in care in inflammatory bowel disease could also be advanced by improving service provision. For example, the establishment of 'Centres of Excellence', a global interactive inflammatory disease map, and the alignment of processes and standards of care within treatment centres may help to achieve better outcomes for patients with inflammatory bowel disease. Realization of this goal, as well as a better understanding of the aetiology of the disease, may be furthered by collaborative efforts between organizations involved in inflammatory bowel disease as well as wider collaboration across countries and globally.
KW - Biomarkers
KW - Calprotectin
KW - Crohn's disease
KW - Inflammatory bowel disease
KW - Translational research
KW - Ulcerative colitis
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U2 - 10.1016/S1873-9946(12)60506-6
DO - 10.1016/S1873-9946(12)60506-6
M3 - Article
C2 - 22463933
AN - SCOPUS:84859023874
SN - 1873-9946
VL - 6
SP - S260-S267
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - SUPPL.2
ER -