What controls aqueous humour outflow resistance?

Mark Johnson*

*Corresponding author for this work

Research output: Contribution to journalReview article

243 Citations (Scopus)

Abstract

The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.

Original languageEnglish (US)
Pages (from-to)545-557
Number of pages13
JournalExperimental eye research
Volume82
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Aqueous Humor
Endothelium
Vacuoles
Basement Membrane
Glaucoma
Connective Tissue
Extracellular Matrix
Endothelial Cells
Perfusion

Keywords

  • Glaucoma
  • Hydraulic conductivity
  • Schlemm's canal

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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title = "What controls aqueous humour outflow resistance?",
abstract = "The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.",
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What controls aqueous humour outflow resistance? / Johnson, Mark.

In: Experimental eye research, Vol. 82, No. 4, 01.04.2006, p. 545-557.

Research output: Contribution to journalReview article

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T1 - What controls aqueous humour outflow resistance?

AU - Johnson, Mark

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.

AB - The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.

KW - Glaucoma

KW - Hydraulic conductivity

KW - Schlemm's canal

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