What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth

Steve N. Caritis*, Maisa N. Feghali, William A. Grobman, Dwight J. Rouse

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Despite major advances in neonatal care, the burden of preterm birth remains high. This is not unexpected since strategies to identify and treat risk factors in early pregnancy have not been very effective in reducing the preterm birth rate. Initial studies suggested a potential benefit for 17-alpha-hydroxyprogesterone caproate (17-OHPC) in decreasing the risk of recurrent preterm birth women with a singleton gestation. However, the use of 17-OHPC has not conferred benefit for other categories of women at high risk for preterm delivery (twins, triplets, and short cervical length). The increasing body of evidence suggests that preterm birth is a complex condition with variable mechanisms of disease and significant individual heterogeneity. This review will examine the plausibility of 17-OHPC in preventing preterm birth and the investigation of its clinical efficacy. We will also highlight factors to explain variations in clinical trial outcomes and outline the trajectory needed for future investigations.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalSeminars in Perinatology
Volume40
Issue number5
DOIs
StatePublished - Aug 1 2016

Keywords

  • 17-alpha-hydroxyprogesterone caproate
  • Preterm birth
  • Prevention

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth'. Together they form a unique fingerprint.

Cite this