TY - JOUR
T1 - Wheezing Exacerbations in Early Childhood
T2 - Evaluation, Treatment, and Recent Advances Relevant to the Genesis of Asthma
AU - Miller, E. Kathryn
AU - Avila, Pedro C.
AU - Khan, Yasmin W.
AU - Word, Carolyn R.
AU - Pelz, Barry J.
AU - Papadopoulos, Nikolaos G.
AU - Peebles, R. Stokes
AU - Heymann, Peter W.
N1 - Publisher Copyright:
© 2014 American Academy of Allergy, Asthma & Immunology.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Children who begin wheezing during early childhood are frequently seen by health care providers in primary care, in hospitals, and in emergency departments, and by allergists and pulmonologists. When a young child, such as the 2 year-old patient presented here, is evaluated for wheezing, a frequent challenge for clinicians is to determine whether the symptoms represent transient, viral-induced wheezing or whether sufficient risk factors are present to suspect that the child may experience recurrent wheezing and develop asthma. Most factors that influence prognosis are not mutually exclusive, are interrelated (ie, cofactors), and often represent gene-environment interactions. Many of these risk factors have been, and continue to be, investigated in prospective studies to decipher their relative importance with the goal of developing new therapies and interventions in the future. The etiologies of wheezing in young children, diagnostic methods, treatment, prognostic factors, and potential targets for prevention of the development of asthma are discussed.
AB - Children who begin wheezing during early childhood are frequently seen by health care providers in primary care, in hospitals, and in emergency departments, and by allergists and pulmonologists. When a young child, such as the 2 year-old patient presented here, is evaluated for wheezing, a frequent challenge for clinicians is to determine whether the symptoms represent transient, viral-induced wheezing or whether sufficient risk factors are present to suspect that the child may experience recurrent wheezing and develop asthma. Most factors that influence prognosis are not mutually exclusive, are interrelated (ie, cofactors), and often represent gene-environment interactions. Many of these risk factors have been, and continue to be, investigated in prospective studies to decipher their relative importance with the goal of developing new therapies and interventions in the future. The etiologies of wheezing in young children, diagnostic methods, treatment, prognostic factors, and potential targets for prevention of the development of asthma are discussed.
KW - Asthma
KW - Childhood
KW - Virus
KW - Wheezing
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U2 - 10.1016/j.jaip.2014.06.024
DO - 10.1016/j.jaip.2014.06.024
M3 - Article
C2 - 25213046
AN - SCOPUS:84924548922
VL - 2
SP - 537
EP - 543
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
SN - 2213-2198
IS - 5
ER -