When evidence is lacking: A mixed-methods approach for the development of practice guidance in liver transplantation

Lisa B. Vanwagner*, Blessing Aghaulor, Tasmeen Hussain, Megan Kosirog, Patrick Campbell, Stewart Pine, Amna Daud, Daniel J. Finn, Josh Levitsky, Donald M. Lloyd-Jones, Jane L. Holl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Most interventions for conditions with a small cohort size, such as transplantation, are unlikely to be part of a clinical trial. When condition-specific evidence is lacking, expert consensus can offer more precise guidance to improve care. Management of cardiovascular risk in liver-transplant recipients is one example for which clinicians have, to date, adapted evidence-based guidelines from studies in the general population. However, even when consensus is achieved, implementation of practice guidance is often inadequate and protracted. We report on a novel mixed-methods approach, the Northwestern Method.

Original languageEnglish (US)
Pages (from-to)22-30
Number of pages9
JournalGastroenterology Report
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • consensus
  • liver transplantation
  • methodology
  • practice guideline

ASJC Scopus subject areas

  • Gastroenterology

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