When less is more: Novel mechanisms of iron conservation

Marina Bayeva, Hsiang Chun Chang, Rongxue Wu, Hossein Ardehali*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Disorders of iron homeostasis are very common, yet the molecular mechanisms of iron regulation remain understudied. Over 20 years have passed since the first characterization of iron-regulatory proteins (IRP) as mediators of cellular iron-deficiency response in mammals through iron acquisition. However, little is known about other mechanisms necessary for adaptation to low-iron states. In this review, we present recent evidence that establishes the existence of a new iron-regulatory pathway aimed at iron conservation and optimization of iron use through suppression of nonessential iron-consuming processes. Moreover, we discuss the possible links between iron homeostasis and energy metabolism uncovered by studies of iron-deficiency response.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalTrends in Endocrinology and Metabolism
Issue number11
StatePublished - Nov 2013


  • Cth1/2
  • Diabetes
  • Iron deficiency
  • Metabolism
  • Tristetraprolin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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