When to Believe What You See

Jennifer A. Nelson, Olke C. Uhlenbeck*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

49 Scopus citations


The recent X-ray crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni containing the rate-enhancing peripheral domain has a catalytic core that is very different from the catalytic core present in the structure of the "minimal" hammerhead, which lacks a peripheral domain (Martick and Scott, 2006). The new structure reconciles many of the disagreements between the minimal hammerhead structure and the biochemical data on the cleavage properties of chemically modified hammerheads. The new structure also emphasizes the dynamic nature of small RNA domains and provides a cautionary tale for everyone who tries to use structure to understand function.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalMolecular cell
Issue number4
StatePublished - Aug 18 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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