When to Believe What You See

Jennifer A. Nelson, Olke C Uhlenbeck*

*Corresponding author for this work

Research output: Contribution to journalShort survey

46 Citations (Scopus)

Abstract

The recent X-ray crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni containing the rate-enhancing peripheral domain has a catalytic core that is very different from the catalytic core present in the structure of the "minimal" hammerhead, which lacks a peripheral domain (Martick and Scott, 2006). The new structure reconciles many of the disagreements between the minimal hammerhead structure and the biochemical data on the cleavage properties of chemically modified hammerheads. The new structure also emphasizes the dynamic nature of small RNA domains and provides a cautionary tale for everyone who tries to use structure to understand function.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalMolecular Cell
Volume23
Issue number4
DOIs
StatePublished - Aug 18 2006

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Catalytic Domain
Schistosoma mansoni
X-Rays
RNA
hammerhead ribozyme

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Nelson, Jennifer A. ; Uhlenbeck, Olke C. / When to Believe What You See. In: Molecular Cell. 2006 ; Vol. 23, No. 4. pp. 447-450.
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When to Believe What You See. / Nelson, Jennifer A.; Uhlenbeck, Olke C.

In: Molecular Cell, Vol. 23, No. 4, 18.08.2006, p. 447-450.

Research output: Contribution to journalShort survey

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AB - The recent X-ray crystal structure of a hammerhead ribozyme derived from Schistosoma mansoni containing the rate-enhancing peripheral domain has a catalytic core that is very different from the catalytic core present in the structure of the "minimal" hammerhead, which lacks a peripheral domain (Martick and Scott, 2006). The new structure reconciles many of the disagreements between the minimal hammerhead structure and the biochemical data on the cleavage properties of chemically modified hammerheads. The new structure also emphasizes the dynamic nature of small RNA domains and provides a cautionary tale for everyone who tries to use structure to understand function.

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