TY - JOUR
T1 - Where is the trace in trace conditioning?
AU - Woodruff-Pak, Diana S.
AU - Disterhoft, John F.
N1 - Funding Information:
We would like to thank Steven Purcell and Roberto Galvez for their contributions to Figure 1 , and Craig Weiss for his contribution to Figure 3 . Comments on and suggestions for the manuscript by Indira Raman and Craig Weiss are very much appreciated. This research was supported by grants from the National Institute on Aging, 1 R01 AG021925 and 1 R01 AG023742, to D.S.W-P. and from the National Institute of Mental Health, 1 R01 MH47340, and the National Institute on Aging, 2 R37 AG08796, to J.F.D.
PY - 2008/2
Y1 - 2008/2
N2 - Intensive mapping of the essential cerebellar brain circuits for Pavlovian eyeblink conditioning appeared relatively complete by 2000, but new data indicate the need for additional differentiation of cerebellar regions and mechanisms coding delay and trace conditioning. This is especially important, as trace conditioning is an experimentally tractable model of declarative learning. The temporal gap in trace eyeblink conditioning may be bridged by forebrain regions through pontine-cerebellar nuclear connections that can bypass cerebellar cortex, whereas a cerebellar cortical long-term-depression-like process appears to be required to support normal delay conditioning. Experiments focusing on the role of cerebellar cortex and deep nuclei in delay versus trace conditioning add perspective on brain substrates of these seemingly similar paradigms, which differ only by a brief stimulus-free time gap between conditioned and unconditioned stimuli. This temporal gap appears to impose forebrain dependencies and differentially engage different cerebellar circuitry during acquisition of conditioned responses.
AB - Intensive mapping of the essential cerebellar brain circuits for Pavlovian eyeblink conditioning appeared relatively complete by 2000, but new data indicate the need for additional differentiation of cerebellar regions and mechanisms coding delay and trace conditioning. This is especially important, as trace conditioning is an experimentally tractable model of declarative learning. The temporal gap in trace eyeblink conditioning may be bridged by forebrain regions through pontine-cerebellar nuclear connections that can bypass cerebellar cortex, whereas a cerebellar cortical long-term-depression-like process appears to be required to support normal delay conditioning. Experiments focusing on the role of cerebellar cortex and deep nuclei in delay versus trace conditioning add perspective on brain substrates of these seemingly similar paradigms, which differ only by a brief stimulus-free time gap between conditioned and unconditioned stimuli. This temporal gap appears to impose forebrain dependencies and differentially engage different cerebellar circuitry during acquisition of conditioned responses.
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U2 - 10.1016/j.tins.2007.11.006
DO - 10.1016/j.tins.2007.11.006
M3 - Review article
C2 - 18199490
AN - SCOPUS:39149106740
SN - 0378-5912
VL - 31
SP - 105
EP - 112
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 2
ER -