Which intraoperative parathyroid hormone assay criterion best predicts operative success? A study of 352 consecutive patients

Bill Chiu, Cord Sturgeon, Peter Angelos*, Gary B. Talpos, Clive S. Grant, Samuel Snyder, Melanie Richards, Quan Yang Duh

*Corresponding author for this work

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Hypothesis: The 6 published criteria for predicting curative parathyroid resection by means of intraoperative parathyroid hormone (IOPTH) assay are not equivalent. Design: Retrospective review of 352 patients undergoing parathyroidectomy for primary hyperparathyroidism from January 1, 1999, to December 31, 2004. We evaluated 6-month postoperative IOPTH values and serum calcium levels. Setting: Tertiary referral center. Main Outcome Measures: The IOPTH values at baseline (preincision and preexcision) and at 5 and 10 minutes after parathyroidectomy were reviewed according to the Miami criterion (>50% drop from highest baseline IOPTH level at 10 minutes after excision), criterion 1 (>50% drop from preincision IOPTH level at 10 minutes), criterion 2 (>50% drop from highest baseline IOPTH level at 10 minutes and final IOPTH level within the reference range), criterion 3 (>50% drop from highest baseline IOPTH level at 10 minutes and final IOPTH level less than the preincision value), criterion 4 (>50% drop from highest baseline IOPTH level at 5 minutes), and criterion 5 (>50% drop from preexcision IOPTH level at 10 minutes). Results: Criterion 2 had sensitivity of 88%, specificity of 22%, positive predictive value of 97%, and negative predictive value of 6%. Criterion 2 had good agreement with criteria 1 and 3. Of patients whose IOPTH level drop satisfied criterion 2 but not criterion 1, 14% had postoperative hypercalcemia at 6 months. When criterion 2 was not satisfied but criteria 1, 3, 4, and 5 and the Miami criterion were, failure rates were 0%, 4%, 7%, 6%, and 9%, respectively. Conclusions: Satisfying criterion 2 had a high operative success but resulted in additional unnecessary surgical exploration. Criterion 1 was better at predicting postoperative normocalcemia than criterion 2.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalArchives of Surgery
Volume141
Issue number5
DOIs
StatePublished - May 1 2006

ASJC Scopus subject areas

  • Surgery

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