White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia

Emily J. Braun; Anne Billot; Erin L. Meier; Yue Pan; Todd B. Parrish; Ajay S. Kurani; Swathi Kiran

doi:10.1016/j.bandl.2022.105163

White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia

Emily J. Braun^*, Anne Billot, Erin L. Meier, Yue Pan, Todd B. Parrish, Ajay S. Kurani, Swathi Kiran

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior longitudinal, and arcuate fasciculi were related to aphasia severity and diffusion measures of the left inferior longitudinal fasciculus were related to naming and treatment response. This study also found preliminary evidence of left inferior longitudinal fasciculus microstructural changes following treatment.

Original language	English (US)
Article number	105163
Journal	Brain and Language
Volume	232
DOIs	https://doi.org/10.1016/j.bandl.2022.105163
State	Published - Sep 2022

Keywords

Aphasia
Automated fiber quantification
Diffusion tensor imaging
Language
Rehabilitation
Stroke
Tractography
White matter

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Language and Linguistics
Linguistics and Language
Cognitive Neuroscience
Speech and Hearing

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10.1016/j.bandl.2022.105163

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title = "White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia",

abstract = "While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior longitudinal, and arcuate fasciculi were related to aphasia severity and diffusion measures of the left inferior longitudinal fasciculus were related to naming and treatment response. This study also found preliminary evidence of left inferior longitudinal fasciculus microstructural changes following treatment.",

keywords = "Aphasia, Automated fiber quantification, Diffusion tensor imaging, Language, Rehabilitation, Stroke, Tractography, White matter",

author = "Braun, {Emily J.} and Anne Billot and Meier, {Erin L.} and Yue Pan and Parrish, {Todd B.} and Kurani, {Ajay S.} and Swathi Kiran",

note = "Funding Information: This work was supported by NIH/NIDCD P50DC012283 and NIH/NIDCD T32DC013017. The authors acknowledge our research participants who generously gave their time and energy during evaluation and treatment for this study. The authors also acknowledge the members of the Aphasia Research Laboratory at Boston University for many helpful discussions and Jeffrey Johnson and Natalie Gilmore for data collection. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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doi = "10.1016/j.bandl.2022.105163",

language = "English (US)",

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AU - Parrish, Todd B.

AU - Kurani, Ajay S.

AU - Kiran, Swathi

N1 - Funding Information: This work was supported by NIH/NIDCD P50DC012283 and NIH/NIDCD T32DC013017. The authors acknowledge our research participants who generously gave their time and energy during evaluation and treatment for this study. The authors also acknowledge the members of the Aphasia Research Laboratory at Boston University for many helpful discussions and Jeffrey Johnson and Natalie Gilmore for data collection. Publisher Copyright: © 2022 Elsevier Inc.

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N2 - While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior longitudinal, and arcuate fasciculi were related to aphasia severity and diffusion measures of the left inferior longitudinal fasciculus were related to naming and treatment response. This study also found preliminary evidence of left inferior longitudinal fasciculus microstructural changes following treatment.

AB - While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior longitudinal, and arcuate fasciculi were related to aphasia severity and diffusion measures of the left inferior longitudinal fasciculus were related to naming and treatment response. This study also found preliminary evidence of left inferior longitudinal fasciculus microstructural changes following treatment.

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White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia

Abstract

Keywords

ASJC Scopus subject areas

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