Abstract
This narrative review explores the pathophysiology, geographic variation, and historical de-velopments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed.
Original language | English (US) |
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Article number | 320 |
Pages (from-to) | 1-17 |
Number of pages | 17 |
Journal | Journal of Clinical Medicine |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - Jan 2 2021 |
Keywords
- Blood component transfusion
- Blood transfusion
- Exsanguination
- Fibrinogen
- Hemostat-ics
- Thromboelastography
ASJC Scopus subject areas
- Medicine(all)