Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus

Jonathan L. Levinsohn; Li C. Tian; Lynn M. Boyden; Jennifer M. McNiff; Deepak Narayan; Erin S. Loring; Duri Yun; Jeffrey L. Sugarman; John D. Overton; Shrikant M. Mane; Richard P. Lifton; Amy S. Paller; Annette M. Wagner; Richard J. Antaya; Keith A. Choate

doi:10.1038/jid.2012.379

Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus

Jonathan L. Levinsohn^*, Li C. Tian, Lynn M. Boyden, Jennifer M. McNiff, Deepak Narayan, Erin S. Loring, Duri Yun, Jeffrey L. Sugarman, John D. Overton, Shrikant M. Mane, Richard P. Lifton, Amy S. Paller, Annette M. Wagner, Richard J. Antaya, Keith A. Choate

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

60 Scopus citations

Original language	English (US)
Pages (from-to)	827-830
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	133
Issue number	3
DOIs	https://doi.org/10.1038/jid.2012.379
State	Published - Mar 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1038/jid.2012.379

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Levinsohn, J. L., Tian, L. C., Boyden, L. M., McNiff, J. M., Narayan, D., Loring, E. S., Yun, D., Sugarman, J. L., Overton, J. D., Mane, S. M., Lifton, R. P., Paller, A. S., Wagner, A. M., Antaya, R. J., & Choate, K. A. (2013). Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus. Journal of Investigative Dermatology, 133(3), 827-830. https://doi.org/10.1038/jid.2012.379

Levinsohn, Jonathan L. ; Tian, Li C. ; Boyden, Lynn M. ; McNiff, Jennifer M. ; Narayan, Deepak ; Loring, Erin S. ; Yun, Duri ; Sugarman, Jeffrey L. ; Overton, John D. ; Mane, Shrikant M. ; Lifton, Richard P. ; Paller, Amy S. ; Wagner, Annette M. ; Antaya, Richard J. ; Choate, Keith A. / Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus. In: Journal of Investigative Dermatology. 2013 ; Vol. 133, No. 3. pp. 827-830.

@article{9055288404df44e7a347cc69fafb2ea8,

title = "Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus",

author = "Levinsohn, {Jonathan L.} and Tian, {Li C.} and Boyden, {Lynn M.} and McNiff, {Jennifer M.} and Deepak Narayan and Loring, {Erin S.} and Duri Yun and Sugarman, {Jeffrey L.} and Overton, {John D.} and Mane, {Shrikant M.} and Lifton, {Richard P.} and Paller, {Amy S.} and Wagner, {Annette M.} and Antaya, {Richard J.} and Choate, {Keith A.}",

note = "Funding Information: We thank Gerald Goh, Emily Hast, Vincent Klump, Akdes Serin, and Jade Wititsuwannakul for technical assistance, Ben Yu for careful discussion of data and potential mechanisms, and Murat Gunel for helpful conversations. This work was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award to KAC, who is also the recipient of a NIH/NIAMS K08 award (K08AR056305), and by the Yale Center for Mendelian Genomics (NIH U54 HG006504). JLL is the recipient of a NIH-NHLBI Medical Student Research Fellowship. This report was concurrently submitted with the publication of Bryan K. Sun, Andrea Saggini, Kavita Y. Sarin, Jinah Kim, Latanya Benjamin, Philip E. LeBoit, and Paul A. Khavari (2012) Mosaic activating RAS mutations in nevus sebaceus and nevus sebaceus syndrome. ",

year = "2013",

month = mar,

doi = "10.1038/jid.2012.379",

language = "English (US)",

volume = "133",

pages = "827--830",

journal = "Journal of Investigative Dermatology",

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Levinsohn, JL, Tian, LC, Boyden, LM, McNiff, JM, Narayan, D, Loring, ES, Yun, D, Sugarman, JL, Overton, JD, Mane, SM, Lifton, RP, Paller, AS , Wagner, AM, Antaya, RJ & Choate, KA 2013, 'Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus', Journal of Investigative Dermatology, vol. 133, no. 3, pp. 827-830. https://doi.org/10.1038/jid.2012.379

Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus. / Levinsohn, Jonathan L.; Tian, Li C.; Boyden, Lynn M.; McNiff, Jennifer M.; Narayan, Deepak; Loring, Erin S.; Yun, Duri; Sugarman, Jeffrey L.; Overton, John D.; Mane, Shrikant M.; Lifton, Richard P.; Paller, Amy S.; Wagner, Annette M.; Antaya, Richard J.; Choate, Keith A.

In: Journal of Investigative Dermatology, Vol. 133, No. 3, 03.2013, p. 827-830.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus

AU - Levinsohn, Jonathan L.

AU - Tian, Li C.

AU - Boyden, Lynn M.

AU - McNiff, Jennifer M.

AU - Narayan, Deepak

AU - Loring, Erin S.

AU - Yun, Duri

AU - Sugarman, Jeffrey L.

AU - Overton, John D.

AU - Mane, Shrikant M.

AU - Lifton, Richard P.

AU - Paller, Amy S.

AU - Wagner, Annette M.

AU - Antaya, Richard J.

AU - Choate, Keith A.

N1 - Funding Information: We thank Gerald Goh, Emily Hast, Vincent Klump, Akdes Serin, and Jade Wititsuwannakul for technical assistance, Ben Yu for careful discussion of data and potential mechanisms, and Murat Gunel for helpful conversations. This work was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award to KAC, who is also the recipient of a NIH/NIAMS K08 award (K08AR056305), and by the Yale Center for Mendelian Genomics (NIH U54 HG006504). JLL is the recipient of a NIH-NHLBI Medical Student Research Fellowship. This report was concurrently submitted with the publication of Bryan K. Sun, Andrea Saggini, Kavita Y. Sarin, Jinah Kim, Latanya Benjamin, Philip E. LeBoit, and Paul A. Khavari (2012) Mosaic activating RAS mutations in nevus sebaceus and nevus sebaceus syndrome.

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Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus

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