Why Does TNA Cross-Pair More Strongly with RNA Than with DNA? An Answer from X-ray Analysis

Pradeep S. Pallan, Christopher J. Wilds, Zdzislaw Wawrzak, Ramanarayanan Krishnamurthy, Albert Eschenmoser, Martin Egli*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    51 Scopus citations

    Abstract

    The TNA twist: L-α-threofuranosyl (3′↔2′) nucleic acid (TNA) residues adopt a C4′-exo pucker when incorporated into an A-(left) or a B-form DNA duplex (right). The resulting intranucleotide P⋯P distance in TNA is very similar to that in RNA (represented by a C3′-endo puckered adenosine residue; green). The structural data explain earlier observations that TNA hydridizes more stably with RNA than with DNA and that RNA constitutes the better template for ligating TNA fragments.

    Original languageEnglish (US)
    Pages (from-to)5893-5895
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Volume42
    Issue number47
    DOIs
    StatePublished - Dec 8 2003

    Keywords

    • Conformation analysis
    • DNA
    • RNA
    • Structure elucidation
    • TNA

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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