Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis

Priyanka Iyer; Yvonne C. Lee

doi:10.1016/j.rdc.2020.12.008

Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis

Priyanka Iyer^*, Yvonne C. Lee

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest.

Original language	English (US)
Pages (from-to)	229-244
Number of pages	16
Journal	Rheumatic Disease Clinics of North America
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.rdc.2020.12.008
State	Published - May 2021

Keywords

Algogens
Central nervous system
Pain mechanisms
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology

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10.1016/j.rdc.2020.12.008

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title = "Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis",

abstract = "Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest.",

keywords = "Algogens, Central nervous system, Pain mechanisms, Rheumatoid arthritis",

author = "Priyanka Iyer and Lee, {Yvonne C.}",

note = "Funding Information: P. Iyer: Have nothing to disclose. Y.C. Lee: Research support from Pfizer; consulting for Highland Instruments; stock in Cigna-Express Scripts; unpaid consulting for Sanofi and Eli Lilly. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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T2 - The Mechanisms of Pain in Rheumatoid Arthritis

AU - Iyer, Priyanka

AU - Lee, Yvonne C.

N1 - Funding Information: P. Iyer: Have nothing to disclose. Y.C. Lee: Research support from Pfizer; consulting for Highland Instruments; stock in Cigna-Express Scripts; unpaid consulting for Sanofi and Eli Lilly. Publisher Copyright: © 2020 Elsevier Inc.

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N2 - Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest.

AB - Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest.

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KW - Central nervous system

KW - Pain mechanisms

KW - Rheumatoid arthritis

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ER -

Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis

Abstract

Keywords

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