Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis

Priyanka Iyer*, Yvonne C. Lee

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest.

Original languageEnglish (US)
Pages (from-to)229-244
Number of pages16
JournalRheumatic Disease Clinics of North America
Issue number2
StatePublished - May 2021


  • Algogens
  • Central nervous system
  • Pain mechanisms
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology


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