TY - JOUR
T1 - Will targeting insulin growth factor help us or hurt us?
T2 - An oncologist's perspective
AU - Kamrava, Mitchell
AU - Gius, David
AU - Casagrande, Giovanna
AU - Kohn, Elise
PY - 2011/1
Y1 - 2011/1
N2 - The insulin/insulin growth factor (IGF) pathway is a critical mediator of longevity and aging. Efforts to extend longevity by altering the insulin/IGF pathway may have varying effects on other physiological processes. Reduced insulin/IGF levels may decrease the incidence of certain cancers as well as the risk of developing metastatic disease. However, it may also increase the risk of developing cardiovascular disease as well as cardiovascular related mortality. Pursuing the right insulin/IGF pathway targets will require striking a balance between inhibiting cancer cell development and progression and avoiding damage to tissues under normal insulin/IGF-mediated control. This review will discuss the roles of the insulin/IGF pathway in aging and longevity and the development of cancer cell metastasis and considerations in taking insulin/IGF directed targets to the oncology clinic.
AB - The insulin/insulin growth factor (IGF) pathway is a critical mediator of longevity and aging. Efforts to extend longevity by altering the insulin/IGF pathway may have varying effects on other physiological processes. Reduced insulin/IGF levels may decrease the incidence of certain cancers as well as the risk of developing metastatic disease. However, it may also increase the risk of developing cardiovascular disease as well as cardiovascular related mortality. Pursuing the right insulin/IGF pathway targets will require striking a balance between inhibiting cancer cell development and progression and avoiding damage to tissues under normal insulin/IGF-mediated control. This review will discuss the roles of the insulin/IGF pathway in aging and longevity and the development of cancer cell metastasis and considerations in taking insulin/IGF directed targets to the oncology clinic.
KW - Aging
KW - Cancer
KW - Insulin growth factor
UR - http://www.scopus.com/inward/record.url?scp=78650232632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650232632&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2009.10.007
DO - 10.1016/j.arr.2009.10.007
M3 - Review article
C2 - 19896561
AN - SCOPUS:78650232632
VL - 10
SP - 62
EP - 70
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
IS - 1
ER -