Wilms tumor

Luke Pater, Patrick Melchior, Christian Rübe, Benjamin T. Cooper, Mary Fran McAleer, John A. Kalapurakal, Arnold C. Paulino*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Although the timing of surgery is different in COG (upfront surgery) and SIOP (upfront chemotherapy with delayed surgery), both are effective strategies and have the same survival. Fewer patients are treated with radiotherapy in the SIOP trials but with higher doses. The prognostic significance of biological markers such as 1q gain and clinical outcomes with novel radiation techniques such as intensity modulated radiation therapy will be determined in upcoming clinical trials. A closer collaboration between COG and SIOP could help promote research and improve the clinical outcomes of children with Wilms tumor.

Original languageEnglish (US)
Article numbere28257
JournalPediatric Blood and Cancer
Volume68
Issue numberS2
DOIs
StateAccepted/In press - 2020

Keywords

  • Wilms tumor
  • chemotherapy
  • radiation therapy
  • surgery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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