Wilms Tumors

Elizabeth J Perlman*, Peter Hohenstein

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Wilms tumors are pediatric tumors of the kidney found in young children with a mean age of 40 months. Genes found mutated in Wilms tumors have essential functions in the early stages of nephron development. Different subsets of Wilms tumors can be recognized via genetic and transcriptomic analysis and ontological analysis of expression patterns suggests different developmental origins for different tumor classes. A better understanding of normal early kidney development will help the design of new therapeutic approaches for different classes of Wilms tumors.

Original languageEnglish (US)
Title of host publicationCancer Genomics
Subtitle of host publicationFrom Bench to Personalized Medicine
PublisherElsevier Inc.
Pages397-413
Number of pages17
ISBN (Print)9780123969675
DOIs
StatePublished - Dec 1 2013

Keywords

  • Beta-catenin
  • IGF2
  • Kidney development
  • Mesenchymal-to-epithelial transition
  • Nephroblastomas
  • Pediatric kidney cancer
  • WNT signaling
  • WT1
  • WTX
  • Wilms tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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