Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models

Philipp Gutruf*, Rose T. Yin, K. Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, Roberto Peralta, Olivia Talarico, Alejandro Murillo, Sheena W. Chen, John P. Leshock, Chad R. Haney, Emily A. Waters, Changxing Zhang, Haiwen Luan, Yonggang Huang, Gregory Trachiotis, Igor R. Efimov, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stability and excellent biocompatibility. Optogenetic stimulation of cardiac cycles with in-animal control and induction of heart failure through chronic pacing serve as examples of modes of operation relevant to fundamental and applied cardiovascular research and biomedical technology.

Original languageEnglish (US)
Article number5742
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Optogenetics
Pacemakers
animal models
animals
electric batteries
Animals
Animal Models
Electric Stimulation Therapy
gene therapy
pulse communication
Gene therapy
pathogenesis
Biomedical Technology
phenotype
Energy harvesting
biocompatibility
Weighing
stimulation
Biocompatibility
Genetic Therapy

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Gutruf, Philipp ; Yin, Rose T. ; Lee, K. Benjamin ; Ausra, Jokubas ; Brennan, Jaclyn A. ; Qiao, Yun ; Xie, Zhaoqian ; Peralta, Roberto ; Talarico, Olivia ; Murillo, Alejandro ; Chen, Sheena W. ; Leshock, John P. ; Haney, Chad R. ; Waters, Emily A. ; Zhang, Changxing ; Luan, Haiwen ; Huang, Yonggang ; Trachiotis, Gregory ; Efimov, Igor R. ; Rogers, John A. / Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. In: Nature communications. 2019 ; Vol. 10, No. 1.
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abstract = "Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stability and excellent biocompatibility. Optogenetic stimulation of cardiac cycles with in-animal control and induction of heart failure through chronic pacing serve as examples of modes of operation relevant to fundamental and applied cardiovascular research and biomedical technology.",
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Gutruf, P, Yin, RT, Lee, KB, Ausra, J, Brennan, JA, Qiao, Y, Xie, Z, Peralta, R, Talarico, O, Murillo, A, Chen, SW, Leshock, JP, Haney, CR, Waters, EA, Zhang, C, Luan, H, Huang, Y, Trachiotis, G, Efimov, IR & Rogers, JA 2019, 'Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models', Nature communications, vol. 10, no. 1, 5742. https://doi.org/10.1038/s41467-019-13637-w

Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. / Gutruf, Philipp; Yin, Rose T.; Lee, K. Benjamin; Ausra, Jokubas; Brennan, Jaclyn A.; Qiao, Yun; Xie, Zhaoqian; Peralta, Roberto; Talarico, Olivia; Murillo, Alejandro; Chen, Sheena W.; Leshock, John P.; Haney, Chad R.; Waters, Emily A.; Zhang, Changxing; Luan, Haiwen; Huang, Yonggang; Trachiotis, Gregory; Efimov, Igor R.; Rogers, John A.

In: Nature communications, Vol. 10, No. 1, 5742, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Yin, Rose T.

AU - Lee, K. Benjamin

AU - Ausra, Jokubas

AU - Brennan, Jaclyn A.

AU - Qiao, Yun

AU - Xie, Zhaoqian

AU - Peralta, Roberto

AU - Talarico, Olivia

AU - Murillo, Alejandro

AU - Chen, Sheena W.

AU - Leshock, John P.

AU - Haney, Chad R.

AU - Waters, Emily A.

AU - Zhang, Changxing

AU - Luan, Haiwen

AU - Huang, Yonggang

AU - Trachiotis, Gregory

AU - Efimov, Igor R.

AU - Rogers, John A.

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