@article{45135687872d4297a264238f918674c6,
title = "Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry",
abstract = " Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.",
author = "Hao Zhang and Philipp Gutruf and Kathleen Meacham and Montana, {Michael C.} and Xingyue Zhao and Chiarelli, {Antonio M.} and Abraham V{\'a}zquez-Guardado and Aaron Norris and Luyao Lu and Qinglei Guo and Chenkai Xu and Yixin Wu and Hangbo Zhao and Xin Ning and Wubin Bai and Irawati Kandela and Haney, {Chad R.} and Debashis Chanda and Gereau, {Robert W.} and Rogers, {John A.}",
note = "Funding Information: We thank A. Birkha for processing the microCT images and I. Stepien for providing weight data of mice with subdermal oximeter implants. This research was supported by the Center for Bio-Integrated Electronics at Northwestern University. The work used the Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (DMR-1720139), the State of Illinois, and Northwestern University and facilities at Frederick Seitz Materials Research Laboratory for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. This work was supported by the Developmental Therapeutics Core at Northwestern University and the Robert H. Lurie Comprehensive Cancer Center support grant (NCI CA060553). Publisher Copyright: Copyright {\textcopyright} 2019 The Authors, some rights reserved.",
year = "2019",
doi = "10.1126/sciadv.aaw0873",
language = "English (US)",
volume = "5",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "3",
}
