Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics

Alex Burton; Sofian N. Obaid; Abraham Vázquez-Guardado; Matthew B. Schmit; Tucker Stuart; Le Cai; Zhiyuan Chen; Irawati Kandela; Chad R. Haney; Emily A. Waters; Haijiang Cai; John A. Rogers; Luyao Lu; Philipp Gutruf

doi:10.1073/pnas.1920073117

Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics

Alex Burton, Sofian N. Obaid, Abraham Vázquez-Guardado, Matthew B. Schmit, Tucker Stuart, Le Cai, Zhiyuan Chen, Irawati Kandela, Chad R. Haney, Emily A. Waters, Haijiang Cai, John A. Rogers^*, Luyao Lu, Philipp Gutruf

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research.

Original language	English (US)
Pages (from-to)	2835-2845
Number of pages	11
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	117
Issue number	6
DOIs	https://doi.org/10.1073/pnas.1920073117
State	Published - Feb 11 2020

Funding

ACKNOWLEDGMENTS. We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering–NIH Training Grant We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering–NIH Training Grant T32EB000809 for Biomedical Imaging and Spectroscopy (A.B.); National Heart, Lung, and Blood Institute–NIH Grant 5T32HL007955-19 (J.A.R.); George Washington University Department of Biomedical Engineering startup funds (L.L.); and The University of Arizona Department of Biomedical Engineering startup funds (P.G.). We thank Anlil Brikha for preparations of CT and MRI 3D renderings.

Keywords

Battery-free
Genetically encoded calcium indicator
Neural dynamics
Photometry
Wireless

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.1920073117

Cite this

Burton, A., Obaid, S. N., Vázquez-Guardado, A., Schmit, M. B., Stuart, T., Cai, L., Chen, Z., Kandela, I., Haney, C. R., Waters, E. A., Cai, H., Rogers, J. A., Lu, L., & Gutruf, P. (2020). Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. Proceedings of the National Academy of Sciences of the United States of America, 117(6), 2835-2845. https://doi.org/10.1073/pnas.1920073117

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title = "Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics",

abstract = "Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research.",

keywords = "Battery-free, Genetically encoded calcium indicator, Neural dynamics, Photometry, Wireless",

author = "Alex Burton and Obaid, {Sofian N.} and Abraham V{\'a}zquez-Guardado and Schmit, {Matthew B.} and Tucker Stuart and Le Cai and Zhiyuan Chen and Irawati Kandela and Haney, {Chad R.} and Waters, {Emily A.} and Haijiang Cai and Rogers, {John A.} and Luyao Lu and Philipp Gutruf",

note = "Funding Information: We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering?NIH Training Grant T32EB000809 for Biomedical Imaging and Spectroscopy (A.B.); National Heart, Lung, and Blood Institute?NIH Grant 5T32HL007955-19 (J.A.R.); George Washington University Department of Biomedical Engineering startup funds (L.L.); and The University of Arizona Department of Biomedical Engineering startup funds (P.G.). We thank Anlil Brikha for preparations of CT and MRI 3D renderings. Funding Information: ACKNOWLEDGMENTS. We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering–NIH Training Grant Publisher Copyright: {\textcopyright} 2020 National Academy of Sciences. All rights reserved.",

year = "2020",

month = feb,

day = "11",

doi = "10.1073/pnas.1920073117",

language = "English (US)",

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Burton, A, Obaid, SN, Vázquez-Guardado, A, Schmit, MB, Stuart, T, Cai, L, Chen, Z, Kandela, I, Haney, CR , Waters, EA, Cai, H, Rogers, JA, Lu, L & Gutruf, P 2020, 'Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 6, pp. 2835-2845. https://doi.org/10.1073/pnas.1920073117

Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics. / Burton, Alex; Obaid, Sofian N.; Vázquez-Guardado, Abraham et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 6, 11.02.2020, p. 2835-2845.

Research output: Contribution to journal › Article › peer-review

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AU - Burton, Alex

AU - Obaid, Sofian N.

AU - Vázquez-Guardado, Abraham

AU - Schmit, Matthew B.

AU - Stuart, Tucker

AU - Cai, Le

AU - Chen, Zhiyuan

AU - Kandela, Irawati

AU - Haney, Chad R.

AU - Waters, Emily A.

AU - Cai, Haijiang

AU - Rogers, John A.

AU - Lu, Luyao

AU - Gutruf, Philipp

N1 - Funding Information: We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering?NIH Training Grant T32EB000809 for Biomedical Imaging and Spectroscopy (A.B.); National Heart, Lung, and Blood Institute?NIH Grant 5T32HL007955-19 (J.A.R.); George Washington University Department of Biomedical Engineering startup funds (L.L.); and The University of Arizona Department of Biomedical Engineering startup funds (P.G.). We thank Anlil Brikha for preparations of CT and MRI 3D renderings. Funding Information: ACKNOWLEDGMENTS. We acknowledge funding support from National Institute of Biomedical Imaging and Bioengineering–NIH Training Grant Publisher Copyright: © 2020 National Academy of Sciences. All rights reserved.

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research.

AB - Recording cell-specific neuronal activity while monitoring behaviors of freely moving subjects can provide some of the most significant insights into brain function. Current means for monitoring calcium dynamics in genetically targeted populations of neurons rely on delivery of light and recording of fluorescent signals through optical fibers that can reduce subject mobility, induce motion artifacts, and limit experimental paradigms to isolated subjects in open, two-dimensional (2D) spaces. Wireless alternatives eliminate constraints associated with optical fibers, but their use of head stages with batteries adds bulk and weight that can affect behaviors, with limited operational lifetimes. The systems introduced here avoid drawbacks of both types of technologies, by combining highly miniaturized electronics and energy harvesters with injectable photometric modules in a class of fully wireless, battery-free photometer that is fully implantable subdermally to allow for the interrogation of neural dynamics in freely behaving subjects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditional power supplies. The unique capabilities of these systems, their compatibility with magnetic resonant imaging and computed tomography and the ability to manufacture them with techniques in widespread use for consumer electronics, suggest a potential for broad adoption in neuroscience research.

KW - Battery-free

KW - Genetically encoded calcium indicator

KW - Neural dynamics

KW - Photometry

KW - Wireless

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JF - Proceedings of the National Academy of Sciences of the United States of America

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Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics

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