Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

Jahyun Koo; Matthew R. MacEwan; Seung Kyun Kang; Sang Min Won; Manu Stephen; Paul Gamble; Zhaoqian Xie; Ying Yan; Yu Yu Chen; Jiho Shin; Nathan Birenbaum; Sangjin Chung; Sung Bong Kim; Jawad Khalifeh; Daniel V. Harburg; Kelsey Bean; Michael Paskett; Jeonghyun Kim; Zohny S. Zohny; Seung Min Lee; Ruoyao Zhang; Kaijing Luo; Bowen Ji; Anthony Banks; Hyuck Mo Lee; Younggang Huang; Wilson Z. Ray; John A. Rogers

doi:10.1038/s41591-018-0196-2

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

Jahyun Koo, Matthew R. MacEwan, Seung Kyun Kang, Sang Min Won, Manu Stephen, Paul Gamble, Zhaoqian Xie, Ying Yan, Yu Yu Chen, Jiho Shin, Nathan Birenbaum, Sangjin Chung, Sung Bong Kim, Jawad Khalifeh, Daniel V. Harburg, Kelsey Bean, Michael Paskett, Jeonghyun Kim, Zohny S. Zohny, Seung Min LeeRuoyao Zhang, Kaijing Luo, Bowen Ji, Anthony Banks, Hyuck Mo Lee, Younggang Huang, Wilson Z. Ray, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

381 Scopus citations

Abstract

Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases¹. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function². Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models^3–10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery^11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits¹³. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.

Original language	English (US)
Pages (from-to)	1830-1836
Number of pages	7
Journal	Nature Medicine
Volume	24
Issue number	12
DOIs	https://doi.org/10.1038/s41591-018-0196-2
State	Published - Dec 1 2018

Funding

S.-K.K. is supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2018R1C1B5043901). H.M.L. is supported by a grant from NRF funded by the Korean government (MEST) (2011-0028612). Z.X. acknowledges support from the National Natural Science Foundation of China (grant no.11402134). Y.H. acknowledges support from National Science Foundation (grant nos. 1400169, 1534120, and 1635443). J.A.R. acknowledges support from DARPA and from the Center for Bio-Integrated Electronics at Northwestern University. We thank S. J. Robinson (Beckman Institute, University of Illinois at Urbana-Champaign) and K. Doty (Department of Comparative Biosciences Histology Service Laboratory, University of Illinois at Urbana-Champaign) for histology staining and images that greatly improved the manuscript.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41591-018-0196-2

Cite this

Koo, J., MacEwan, M. R., Kang, S. K., Won, S. M., Stephen, M., Gamble, P., Xie, Z., Yan, Y., Chen, Y. Y., Shin, J., Birenbaum, N., Chung, S., Kim, S. B., Khalifeh, J., Harburg, D. V., Bean, K., Paskett, M., Kim, J., Zohny, Z. S., ... Rogers, J. A. (2018). Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy. Nature Medicine, 24(12), 1830-1836. https://doi.org/10.1038/s41591-018-0196-2

@article{cc19f26814ba4aebb8b31987b461c7c9,

title = "Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy",

abstract = "Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models3–10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits13. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.",

author = "Jahyun Koo and MacEwan, {Matthew R.} and Kang, {Seung Kyun} and Won, {Sang Min} and Manu Stephen and Paul Gamble and Zhaoqian Xie and Ying Yan and Chen, {Yu Yu} and Jiho Shin and Nathan Birenbaum and Sangjin Chung and Kim, {Sung Bong} and Jawad Khalifeh and Harburg, {Daniel V.} and Kelsey Bean and Michael Paskett and Jeonghyun Kim and Zohny, {Zohny S.} and Lee, {Seung Min} and Ruoyao Zhang and Kaijing Luo and Bowen Ji and Anthony Banks and Lee, {Hyuck Mo} and Younggang Huang and Ray, {Wilson Z.} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41591-018-0196-2",

language = "English (US)",

volume = "24",

pages = "1830--1836",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Research",

number = "12",

}

Koo, J, MacEwan, MR, Kang, SK, Won, SM, Stephen, M, Gamble, P, Xie, Z, Yan, Y, Chen, YY, Shin, J, Birenbaum, N, Chung, S, Kim, SB, Khalifeh, J, Harburg, DV, Bean, K, Paskett, M, Kim, J, Zohny, ZS, Lee, SM, Zhang, R, Luo, K, Ji, B, Banks, A, Lee, HM, Huang, Y, Ray, WZ & Rogers, JA 2018, 'Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy', Nature Medicine, vol. 24, no. 12, pp. 1830-1836. https://doi.org/10.1038/s41591-018-0196-2

TY - JOUR

T1 - Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

AU - Koo, Jahyun

AU - MacEwan, Matthew R.

AU - Kang, Seung Kyun

AU - Won, Sang Min

AU - Stephen, Manu

AU - Gamble, Paul

AU - Xie, Zhaoqian

AU - Yan, Ying

AU - Chen, Yu Yu

AU - Shin, Jiho

AU - Birenbaum, Nathan

AU - Chung, Sangjin

AU - Kim, Sung Bong

AU - Khalifeh, Jawad

AU - Harburg, Daniel V.

AU - Bean, Kelsey

AU - Paskett, Michael

AU - Kim, Jeonghyun

AU - Zohny, Zohny S.

AU - Lee, Seung Min

AU - Zhang, Ruoyao

AU - Luo, Kaijing

AU - Ji, Bowen

AU - Banks, Anthony

AU - Lee, Hyuck Mo

AU - Huang, Younggang

AU - Ray, Wilson Z.

AU - Rogers, John A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models3–10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits13. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.

AB - Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases1. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function2. Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models3–10. Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery11,12, suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits13. Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.

UR - http://www.scopus.com/inward/record.url?scp=85054577088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054577088&partnerID=8YFLogxK

U2 - 10.1038/s41591-018-0196-2

DO - 10.1038/s41591-018-0196-2

M3 - Article

C2 - 30297910

AN - SCOPUS:85054577088

SN - 1078-8956

VL - 24

SP - 1830

EP - 1836

JO - Nature Medicine

JF - Nature Medicine

IS - 12

ER -

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this