Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Jokubas Ausra; Micah Madrid; Rose T. Yin; Jessica Hanna; Suzanne Arnott; Jaclyn A. Brennan; Roberto Peralta; David Clausen; Jakob A. Bakall; Igor R. Efimov; Philipp Gutruf

doi:10.1126/sciadv.abq7469

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Jokubas Ausra, Micah Madrid, Rose T. Yin, Jessica Hanna, Suzanne Arnott, Jaclyn A. Brennan, Roberto Peralta, David Clausen, Jakob A. Bakall, Igor R. Efimov^*, Philipp Gutruf^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.

Original language	English (US)
Article number	eabq7469
Journal	Science Advances
Volume	8
Issue number	43
DOIs	https://doi.org/10.1126/sciadv.abq7469
State	Published - Oct 2022

Funding

We acknowledge funding support from the National Heart, Lung, and Blood Institute NIH 5T32HL007955-19 (to J.A.), R01-HL141470 (to I.R.E. and M.M.), and R21-HL152324 (to I.R.E. and M.M.), the Leducq Foundation grant RHYTHM (to I.R.E.), the American Heart Association Predoctoral Fellowship 19PRE34380781 (to R.T.Y.), and the NIH 3OT2OD023848 (to J.A.B.).

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title = "Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation",

abstract = "Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.",

author = "Jokubas Ausra and Micah Madrid and Yin, {Rose T.} and Jessica Hanna and Suzanne Arnott and Brennan, {Jaclyn A.} and Roberto Peralta and David Clausen and Bakall, {Jakob A.} and Efimov, {Igor R.} and Philipp Gutruf",

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AU - Ausra, Jokubas

AU - Madrid, Micah

AU - Yin, Rose T.

AU - Hanna, Jessica

AU - Arnott, Suzanne

AU - Brennan, Jaclyn A.

AU - Peralta, Roberto

AU - Clausen, David

AU - Bakall, Jakob A.

AU - Efimov, Igor R.

AU - Gutruf, Philipp

PY - 2022/10

Y1 - 2022/10

N2 - Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.

AB - Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning–guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.

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Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Abstract

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