Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Hexia Guo; Wubin Bai; Wei Ouyang; Yihan Liu; Changsheng Wu; Yameng Xu; Yang Weng; Hao Zang; Yiming Liu; Lauren Jacobson; Ziying Hu; Yihang Wang; Hany M. Arafa; Quansan Yang; Di Lu; Shuo Li; Lin Zhang; Xun Xiao; Abraham Vázquez-Guardado; Joanna Ciatti; Elizabeth Dempsey; Nayereh Ghoreishi-Haack; Emily A. Waters; Chad R. Haney; Amanda M. Westman; Matthew R. MacEwan; Mitchell A. Pet; John A. Rogers

doi:10.1038/s41467-022-30594-z

Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Hexia Guo, Wubin Bai^*, Wei Ouyang, Yihan Liu, Changsheng Wu, Yameng Xu, Yang Weng, Hao Zang, Yiming Liu, Lauren Jacobson, Ziying Hu, Yihang Wang, Hany M. Arafa, Quansan Yang, Di Lu, Shuo Li, Lin Zhang, Xun Xiao, Abraham Vázquez-Guardado, Joanna CiattiElizabeth Dempsey, Nayereh Ghoreishi-Haack, Emily A. Waters, Chad R. Haney, Amanda M. Westman, Matthew R. MacEwan, Mitchell A. Pet, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O₂-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

Original language	English (US)
Article number	3009
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-30594-z
State	Published - Dec 2022

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)

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10.1038/s41467-022-30594-z

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Guo, H., Bai, W., Ouyang, W., Liu, Y., Wu, C., Xu, Y., Weng, Y., Zang, H., Liu, Y., Jacobson, L., Hu, Z., Wang, Y., Arafa, H. M., Yang, Q., Lu, D., Li, S., Zhang, L., Xiao, X., Vázquez-Guardado, A., ... Rogers, J. A. (2022). Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts. Nature communications, 13(1), [3009]. https://doi.org/10.1038/s41467-022-30594-z

@article{77004144fa374640825d0725b19a0aeb,

title = "Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts",

abstract = "Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.",

author = "Hexia Guo and Wubin Bai and Wei Ouyang and Yihan Liu and Changsheng Wu and Yameng Xu and Yang Weng and Hao Zang and Yiming Liu and Lauren Jacobson and Ziying Hu and Yihang Wang and Arafa, {Hany M.} and Quansan Yang and Di Lu and Shuo Li and Lin Zhang and Xun Xiao and Abraham V{\'a}zquez-Guardado and Joanna Ciatti and Elizabeth Dempsey and Nayereh Ghoreishi-Haack and Waters, {Emily A.} and Haney, {Chad R.} and Westman, {Amanda M.} and MacEwan, {Matthew R.} and Pet, {Mitchell A.} and Rogers, {John A.}",

note = "Funding Information: This work was supported by the Querrey Simpson Institute for Bioelectronics. This work made use of the NUFAB facility of Northwestern University{\textquoteright}s NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern{\textquoteright}s MRSEC program (NSF DMR-1720139). W.B. acknowledges startup funding from UNC Chapel Hill. M.M. and M.P. acknowledge funding for this study, which was received from the Division of Plastic Surgery, Center for Defense Medicine, and the Department of Neurosurgery at Washington University. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-30594-z",

language = "English (US)",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

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Guo, H, Bai, W, Ouyang, W, Liu, Y, Wu, C, Xu, Y, Weng, Y, Zang, H, Liu, Y, Jacobson, L, Hu, Z, Wang, Y, Arafa, HM, Yang, Q, Lu, D, Li, S, Zhang, L, Xiao, X, Vázquez-Guardado, A, Ciatti, J, Dempsey, E, Ghoreishi-Haack, N, Waters, EA , Haney, CR, Westman, AM, MacEwan, MR, Pet, MA & Rogers, JA 2022, 'Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts', Nature communications, vol. 13, no. 1, 3009. https://doi.org/10.1038/s41467-022-30594-z

TY - JOUR

T1 - Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

AU - Guo, Hexia

AU - Bai, Wubin

AU - Ouyang, Wei

AU - Liu, Yihan

AU - Wu, Changsheng

AU - Xu, Yameng

AU - Weng, Yang

AU - Zang, Hao

AU - Liu, Yiming

AU - Jacobson, Lauren

AU - Hu, Ziying

AU - Wang, Yihang

AU - Arafa, Hany M.

AU - Yang, Quansan

AU - Lu, Di

AU - Li, Shuo

AU - Zhang, Lin

AU - Xiao, Xun

AU - Vázquez-Guardado, Abraham

AU - Ciatti, Joanna

AU - Dempsey, Elizabeth

AU - Ghoreishi-Haack, Nayereh

AU - Waters, Emily A.

AU - Haney, Chad R.

AU - Westman, Amanda M.

AU - MacEwan, Matthew R.

AU - Pet, Mitchell A.

AU - Rogers, John A.

N1 - Funding Information: This work was supported by the Querrey Simpson Institute for Bioelectronics. This work made use of the NUFAB facility of Northwestern University’s NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern’s MRSEC program (NSF DMR-1720139). W.B. acknowledges startup funding from UNC Chapel Hill. M.M. and M.P. acknowledge funding for this study, which was received from the Division of Plastic Surgery, Center for Defense Medicine, and the Department of Neurosurgery at Washington University. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

AB - Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

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DO - 10.1038/s41467-022-30594-z

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JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3009

ER -

Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

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