Wireless implantable optical probe for continuous monitoring of oxygen saturation in flaps and organ grafts

Hexia Guo, Wubin Bai*, Wei Ouyang, Yihan Liu, Changsheng Wu, Yameng Xu, Yang Weng, Hao Zang, Yiming Liu, Lauren Jacobson, Ziying Hu, Yihang Wang, Hany M. Arafa, Quansan Yang, Di Lu, Shuo Li, Lin Zhang, Xun Xiao, Abraham Vázquez-Guardado, Joanna CiattiElizabeth Dempsey, Nayereh Ghoreishi-Haack, Emily A. Waters, Chad R. Haney, Amanda M. Westman, Matthew R. MacEwan, Mitchell A. Pet, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Continuous, real-time monitoring of perfusion after microsurgical free tissue transfer or solid organ allotransplantation procedures can facilitate early diagnosis of and intervention for anastomotic thrombosis. Current technologies including Doppler systems, cutaneous O2-sensing probes, and fluorine magnetic resonance imaging methods are limited by their intermittent measurements, requirements for skilled personnel, indirect interfaces, and/or their tethered connections. This paper reports a wireless, miniaturized, minimally invasive near-infrared spectroscopic system designed for uninterrupted monitoring of local-tissue oxygenation. A bioresorbable barbed structure anchors the probe stably at implantation sites for a time period matched to the clinical need, with the ability for facile removal afterward. The probe connects to a skin-interfaced electronic module for wireless access to essential physiological parameters, including local tissue oxygenation, pulse oxygenation, and heart rate. In vitro tests and in vivo studies in porcine flap and kidney models demonstrate the ability of the system to continuously measure oxygenation with high accuracy and sensitivity.

Original languageEnglish (US)
Article number3009
JournalNature communications
Issue number1
StatePublished - Dec 2022

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology


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