Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

Jae Woong Jeong, Jordan G. McCall, Gunchul Shin, Yihui Zhang, Ream Al-Hasani, Minku Kim, Shuo Li, Joo Yong Sim, Kyung In Jang, Yan Shi, Daniel Y. Hong, Yuhao Liu, Gavin P. Schmitz, Li Xia, Zhubin He, Paul Gamble, Wilson Z. Ray, Yonggang Huang, Michael R. Bruchas*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, untethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (μ-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.

Original languageEnglish (US)
Pages (from-to)662-674
Number of pages13
JournalCell
Volume162
Issue number3
DOIs
StatePublished - Aug 1 2015

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Optogenetics
Animals
Pharmacology
Drug delivery
Pharmaceutical Preparations
Biomedical Engineering
Cell signaling
Dissection
Microfluidics
Reward
Gene expression
Fiber optics
Medicine
Light emitting diodes
Metals
Ligands
Technology
Gene Expression
Light
Equipment and Supplies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jeong, J. W., McCall, J. G., Shin, G., Zhang, Y., Al-Hasani, R., Kim, M., ... Rogers, J. A. (2015). Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell, 162(3), 662-674. https://doi.org/10.1016/j.cell.2015.06.058
Jeong, Jae Woong ; McCall, Jordan G. ; Shin, Gunchul ; Zhang, Yihui ; Al-Hasani, Ream ; Kim, Minku ; Li, Shuo ; Sim, Joo Yong ; Jang, Kyung In ; Shi, Yan ; Hong, Daniel Y. ; Liu, Yuhao ; Schmitz, Gavin P. ; Xia, Li ; He, Zhubin ; Gamble, Paul ; Ray, Wilson Z. ; Huang, Yonggang ; Bruchas, Michael R. ; Rogers, John A. / Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. In: Cell. 2015 ; Vol. 162, No. 3. pp. 662-674.
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Jeong, JW, McCall, JG, Shin, G, Zhang, Y, Al-Hasani, R, Kim, M, Li, S, Sim, JY, Jang, KI, Shi, Y, Hong, DY, Liu, Y, Schmitz, GP, Xia, L, He, Z, Gamble, P, Ray, WZ, Huang, Y, Bruchas, MR & Rogers, JA 2015, 'Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics', Cell, vol. 162, no. 3, pp. 662-674. https://doi.org/10.1016/j.cell.2015.06.058

Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. / Jeong, Jae Woong; McCall, Jordan G.; Shin, Gunchul; Zhang, Yihui; Al-Hasani, Ream; Kim, Minku; Li, Shuo; Sim, Joo Yong; Jang, Kyung In; Shi, Yan; Hong, Daniel Y.; Liu, Yuhao; Schmitz, Gavin P.; Xia, Li; He, Zhubin; Gamble, Paul; Ray, Wilson Z.; Huang, Yonggang; Bruchas, Michael R.; Rogers, John A.

In: Cell, Vol. 162, No. 3, 01.08.2015, p. 662-674.

Research output: Contribution to journalArticle

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AU - Jeong, Jae Woong

AU - McCall, Jordan G.

AU - Shin, Gunchul

AU - Zhang, Yihui

AU - Al-Hasani, Ream

AU - Kim, Minku

AU - Li, Shuo

AU - Sim, Joo Yong

AU - Jang, Kyung In

AU - Shi, Yan

AU - Hong, Daniel Y.

AU - Liu, Yuhao

AU - Schmitz, Gavin P.

AU - Xia, Li

AU - He, Zhubin

AU - Gamble, Paul

AU - Ray, Wilson Z.

AU - Huang, Yonggang

AU - Bruchas, Michael R.

AU - Rogers, John A.

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Jeong JW, McCall JG, Shin G, Zhang Y, Al-Hasani R, Kim M et al. Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell. 2015 Aug 1;162(3):662-674. https://doi.org/10.1016/j.cell.2015.06.058