Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

Jae Woong Jeong, Jordan G. McCall, Gunchul Shin, Yihui Zhang, Ream Al-Hasani, Minku Kim, Shuo Li, Joo Yong Sim, Kyung In Jang, Yan Shi, Daniel Y. Hong, Yuhao Liu, Gavin P. Schmitz, Li Xia, Zhubin He, Paul Gamble, Wilson Z. Ray, Yonggang Huang, Michael R. Bruchas*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

192 Scopus citations

Abstract

In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, untethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (μ-ILED) arrays. These probes are orders of magnitude smaller than cannulas and allow wireless, programmed spatiotemporal control of fluid delivery and photostimulation. We demonstrate these devices in freely moving animals to modify gene expression, deliver peptide ligands, and provide concurrent photostimulation with antagonist drug delivery to manipulate mesoaccumbens reward-related behavior. The minimally invasive operation of these probes forecasts utility in other organ systems and species, with potential for broad application in biomedical science, engineering, and medicine.

Original languageEnglish (US)
Pages (from-to)662-674
Number of pages13
JournalCell
Volume162
Issue number3
DOIs
StatePublished - Aug 1 2015

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jeong, J. W., McCall, J. G., Shin, G., Zhang, Y., Al-Hasani, R., Kim, M., Li, S., Sim, J. Y., Jang, K. I., Shi, Y., Hong, D. Y., Liu, Y., Schmitz, G. P., Xia, L., He, Z., Gamble, P., Ray, W. Z., Huang, Y., Bruchas, M. R., & Rogers, J. A. (2015). Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell, 162(3), 662-674. https://doi.org/10.1016/j.cell.2015.06.058